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首页> 外文期刊>Journal of gastroenterology >Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype.
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Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype.

机译：胆囊切除术后胆结石复发与ABCG5 / 8基因型有关。

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Gallstone disease is a frequent and economically highly relevant disorder, with cholecystectomy representing one of the most frequently performed operations world-wide. Gallstone recurrence after cholecystectomy is associated with complications such as biliary sepsis and pancreatitis. As yet, variant ABCG8-D19H is the most widely recognized genetic risk factor for gallstone disease. The aim of the study is to investigate whether ABCG8-D19H is associated with gallstone recurrence after cholecystectomy.Two thousand three hundred and eight patients from an earlier study of gallstone risk factors were re-contacted by mail, leading to 1,915 patients with available clinical and genetic information. Symptomatic gallstone recurrence was established if it occurred more than six months after surgery. Median follow-up time after cholecystectomy was eight years.Gallstones recurred in 37 patients (1.9%). ABCG-D19H was found to be significantly associated with gallstone recurrence (p = 0.034). The allelic odds ratio was 1.97 (95% CI 1.12-∞). In a multivariate logistic regression analysis adjusted for age, sex, BMI and type of surgery, ABCG8-D19H remained a significant predictor, both in the total cohort (p = 0.024) and in the subgroup for whom information on type and scheduling of surgery was available (N = 1,650, p = 0.020).ABCG8-D19H is a predictor of gallstone recurrence, a major long term postoperative biliary complication. Moreover, the observed association also reemphasizes the importance of the sterolin transporter for stone formation.
机译：胆结石病是一种频繁且在经济上高度相关的疾病，胆囊切除术是全球范围内执行最频繁的手术之一。胆囊切除术后胆结石复发与并发症如胆汁败血症和胰腺炎有关。迄今为止，变异ABCG8-D19H是最广泛认可的胆结石疾病的遗传危险因素。这项研究的目的是研究ABCG8-D19H是否与胆囊切除术后胆结石复发有关。通过邮件重新联系了较早研究胆结石危险因素的38.08例患者，导致1,915例临床和遗传信息。如果在手术后六个月以上发生，则有症状性胆结石复发。胆囊切除术后中位随访时间为八年，胆结石复发37例（1.9％）。发现ABCG-D19H与胆结石复发显着相关（p = 0.034）。等位基因比值比为1.97（95％CI1.12-∞）。在对年龄，性别，BMI和手术类型进行调整的多因素logistic回归分析中，ABCG8-D19H仍然是一个重要的预测指标，无论是在总队列中（p = 0.024）还是在亚组中，有关其类型和手术计划的信息可用（N = 1,650，p = 0.020）。ABCG8-D19H是胆结石复发的预测指标，胆结石是术后长期的主要胆道并发症。此外，观察到的关联也再次强调了固醇转运蛋白对于结石的重要性。

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