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首页> 外文期刊>Journal of hepato-biliary-pancreatic surgery >Prognostic factors after recurrence of resected hepatocellular carcinoma associated with hepatitis C virus.
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Prognostic factors after recurrence of resected hepatocellular carcinoma associated with hepatitis C virus.

机译：与丙型肝炎病毒相关的切除的肝细胞癌复发后的预后因素。

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摘要

To clarify the variables related to survival after recurrence of resected hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV), we studied 17 clinicopathological factors in 99 patients with recurrence of HCC associated with HCV infection after hepatic resection. The 1-, 3-, and 5-year survival rates after first resection in these patients were 91%, 81%, and 49%, while after recurrence they were 81%, 51%, and 29%, respectively. Multivariate analysis showed that the following six variables were independent prognostic factors after recurrence: platelet count, albumin level, bilirubin level, number of hepatic lesions, distant metastasis, and any treatment at recurrence. A correlation between second hepatic resection (SHR) and liver function tests was seen in regard to albumin and total bilirubin values at recurrence. Indeed, hepatic function and progression of intrahepatic tumors at recurrence were significant prognostic factors after recurrence of HCC associated with HCV infection, while any treatment at recurrence was also a significant prognostic factor. Therefore, in order to improve prognosis after recurrence, we should actively treat the recurrent hepatic lesions whenever possible.
机译：为了阐明与丙型肝炎病毒（HCV）相关的切除的肝细胞癌（HCC）复发后存活率的相关变量，我们研究了99例肝切除后HCV感染相关的HCC复发患者的17种临床病理因素。这些患者首次切除后的1年，3年和5年生存率分别为91％，81％和49％，而复发后分别为81％，51％和29％。多因素分析显示，以下六个变量是复发后的独立预后因素：血小板计数，白蛋白水平，胆红素水平，肝病变数目，远处转移以及复发时的任何治疗。复发时白蛋白和总胆红素值在第二次肝切除（SHR）和肝功能测试之间存在相关性。确实，复发后肝功能和肝内肿瘤的进展是与HCV感染相关的HCC复发后的重要预后因素，而复发时的任何治疗也是重要的预后因素。因此，为改善复发后的预后，应尽可能积极治疗复发性肝病灶。

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