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首页> 外文期刊>Journal of Hepatology: The Journal of the European Association for the Study of the Liver >Reply to: 'Regular coffee: A magic bullet or a naked gun? Regular coffee but not espresso drinking is protective against fibrosis in NAFLD'
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Reply to: 'Regular coffee: A magic bullet or a naked gun? Regular coffee but not espresso drinking is protective against fibrosis in NAFLD'

机译：回复：“普通咖啡：魔术子弹或裸露的枪？普通咖啡而不是浓咖啡可以预防NAFLD的纤维化”

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摘要

We have read with interest the comments and criticisms made by Trovato and colleagues concerning our recently published study [1]. We would like to clarify a number of specific points. Firstly, we agree that our study population - morbidly obese patients referred for bariatric surgery - is a very particular group; morbidly obese subjects represent one percent of the French population. Our patients were consecutively enrolled in the bariatric program and agreed to complete a detailed questionnaire, given by a trained interviewer, assessing their coffee and caffeinated drink consumption. For each patient, a liver biopsy was obtained and assessed by validated classification. This histological analysis remains the gold standard to determine the various elementary lesions of NAFLD and NASH. This method is reliable and allowed us to differentiate pure steatosis, NASH, and the various degrees of fibrosis, in contrast to the use of only non-invasive methods such as liver ultrasound, as in the study by Catalano et al. [2].
机译：我们感兴趣地阅读了Trovato及其同事对我们最近发表的研究发表的评论和批评[1]。我们想澄清一些具体点。首先，我们同意我们的研究人群-进行减肥手术的病态肥胖患者-是一个非常特殊的群体。病态肥胖的受试者占法国人口的百分之一。我们的患者连续参加了减肥计划，并同意由训练有素的访调员完成一份详细的问卷调查，评估他们的咖啡和含咖啡因的饮料消费量。对于每位患者，均需进行肝活检并通过有效分类进行评估。这种组织学分析仍然是确定NAFLD和NASH各种基本病变的金标准。与Catalano等人的研究仅使用非侵入性方法（例如肝超声）相比，这种方法是可靠的，并且使我们能够区分纯脂肪变性，NASH和各种程度的纤维化。 [2]。

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