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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Mast cells, angiogenesis, and tumour growth
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Mast cells, angiogenesis, and tumour growth

机译：肥大细胞，血管生成和肿瘤生长

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Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis. Since this early account, ample evidence has been provided highlighting participation of MCs to the inflammatory reaction that occurs in many clinical and experimental tumour settings. MCs are bone marrow-derived tissue-homing leukocytes that are endowed with a panoply of releasable mediators and surface receptors. These cells actively take part to innate and acquired immune reactions as well as to a series of fundamental functions such as angiogenesis, tissue repair, and tissue remodelling. The involvement of MCs in tumour development is debated. Although some evidence suggests that MCs can promote tumourigenesis and tumour progression, there are some clinical sets as well as experimental tumour models in which MCs seem to have functions that favour the host. One of the major issues linking MCs to cancer is the ability of these cells to release potent pro-angiogenic factors. This review will focus on the most recent acquisitions about this intriguing field of research. This article is part of a Special Issue entitled: Mast cells in inflammation.
机译：Ehrlich在其博士论文中描述了肿瘤中肥大细胞（MCs）的积累。自从这一早期研究以来，已经提供了足够的证据来强调MC参与了许多临床和实验肿瘤背景中发生的炎症反应。 MC是骨髓来源的组织归巢的白细胞，具有大量可释放的介质和表面受体。这些细胞积极参与先天性和后天性免疫反应以及一系列基本功能，例如血管生成，组织修复和组织重塑。 MC参与肿瘤发展的辩论。尽管一些证据表明MC可以促进肿瘤发生和肿瘤进展，但是在某些临床情况以及实验性肿瘤模型中，MC似乎都具有有利于宿主的功能。将MC与癌症联系起来的主要问题之一是这些细胞释放有效的促血管生成因子的能力。这篇综述将集中在有关这个有趣的研究领域的最新成果。本文是名为“肥大细胞在炎症中”的特刊的一部分。

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