One-pot three-component synthesis of spirooxindoles catalyzed by hexamethylenetetramine in water

Wang G.-D.; Zhang X.-N.; Zhang Z.-H.

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One-pot three-component synthesis of spirooxindoles catalyzed by hexamethylenetetramine in water

机译：六亚甲基四胺在水中一锅三组分合成螺菌灵

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A simple, convenient, and multicomponent strategy for synthesis of spirooxindole derivatives has been developed. This strategy provides a rapid access to construct a diversity-oriented library of spirooxindoles by using three simple and readily available isatin, malononitrile or cyanoacetic ester, and 1,3-dicarbonyl compound catalyzed by hexamethylenetetramine in water.

机译：已经开发了一种简单，方便和多组分合成螺环吲哚衍生物的策略。通过使用三种简单易得的靛红，丙二腈或氰基乙酸酯，以及六亚甲基四胺在水中催化的1,3-二羰基化合物，该策略可快速构建螺菌毒素的面向多样性的文库。

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《Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry》 |2013年第1期|共5页
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Wang G.-D.; Zhang X.-N.; Zhang Z.-H.;
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正文语种 eng
中图分类有机化学;
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1. One-pot three-component synthesis of spirooxindoles catalyzed by hexamethylenetetramine in water [J] . Wang G.-D., Zhang X.-N., Zhang Z.-H. Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2013,第1期

机译：六亚甲基四胺在水中一锅三组分合成螺菌灵
2. One-pot, three-component synthesis of spirooxindoles catalyzed by ZnO nano-rods in solvent-free conditions [J] . Hosseini-SarvariM., TavakolianM. Combinatorial chemistry & high throughput screening . 2012,第10期

机译：ZnO纳米棒在无溶剂条件下一锅三组分合成螺菌灵
3. One-Pot, Three-Component Synthesis of a Library of Spirooxindole-Pyrimidines Catalyzed by Magnetic Nanoparticle Supported Dodecyl Benzenesulfonic Acid in Aqueous Media [J] . Jia Deng, Li-Ping Mo, Fei-Yang Zhao ACS combinatorial science . 2012,第5期

机译：磁性纳米粒子负载十二烷基苯磺酸在水性介质中催化的螺-恶臭嘧啶-嘧啶库的一锅三组分合成
4. One-pot Three-component Synthesis of Spirooxindoles Catalysed by NH4OAc in Water [C] . Peyman Salehi, Minoo Dabiri, Mahboobeh Bahramnejad European Symposium on Organic Chemistry . 2009

机译：NH4OAc在水中刺激素三分合成螺氧吲哚组合
5. Scandium(III)- and Indium(III)-Catalyzed Enantioselective Additions to Isatin for the Synthesis of 3-Hydroxy-2-Oxindoles and [(3'-Trialkylsilyl)- Tetrahydrofuranyl]Spirooxindoles [D] . Hanhan, Nadine Victor 2013

机译：Is（Ⅲ）和铟（Ⅲ）催化的对映体对映选择性加成反应，用于合成3-羟基-2-氧代辛二烯和[（3'-三烷基甲硅烷基）-四氢呋喃基]螺氧基吲哚
6. A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids [O] . Raju Suresh Kumar, Dhaifallah M. Al-thamili, Abdulrahman I. Almansour, 2020

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7. One-Pot, Three-Component Synthesis of 1-(2-Hydroxyethyl)-1H-1,2,3-triazole Derivatives by Copper-Catalyzed 1,3-Dipolar Cycloaddition of 2-Azido Alcohols and Terminal Alkynes under Mild Conditions in Water [O] . Hashem Sharghi, Mona Hosseini-Sarvari, Fatemeh Moeini, 2010

机译：通过铜催化的1,3-偶极醇环加入的2-α醇醇和末端炔烃在水中的温和条件下的1-（2-羟乙基）-1H-1,2,3-三唑衍生物的一锅。

One-pot three-component synthesis of spirooxindoles catalyzed by hexamethylenetetramine in water

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