Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to Amlodipine

Youn A. Lee; Seok Chan Kim

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Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to Amlodipine

机译：微波辅助氮杂-Diels-Alder反应合成1,4-二氢吡啶及其在氨氯地平中的应用

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摘要

We synthesized 1,4-dihydropyridine skeleton using aza-Diels-Alder reaction under the microwave irradiation condition which has become a powerful method for the rapid synthesis of a variety of organic molecules. The prepared 1,4-dihydropyridine product was further converted to antihypertensive drug Amlodipine to test this new methodology.

机译：我们在微波辐射条件下利用aza-Diels-Alder反应合成了1,4-二氢吡啶骨架，这已成为一种快速合成各种有机分子的有力方法。将制备的1,4-二氢吡啶产物进一步转化为降压药氨氯地平以测试该新方法。

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《Journal of industrial and engineering chemistry》 |2011年第3期|共3页
作者
Youn A. Lee; Seok Chan Kim;
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正文语种 eng
中图分类化学工业;
关键词
1; 4-Dihydropyridine; Amlodipine; Aza-Diels-Alder reaction; Microwave-assisted reaction;

机译：1;4-二氢吡啶;氨氯地平;Aza-Diels-Alder反应;微波辅助反应;

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1. Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to Amlodipine [J] . Youn A. Lee, Seok Chan Kim Journal of industrial and engineering chemistry . 2011,第3期

机译：微波辅助氮杂-Diels-Alder反应合成1,4-二氢吡啶及其在氨氯地平中的应用
2. Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents [J] . Baruah B., Naidu P.S., Borah P., Molecular diversity . 2012,第2期

机译：使用Hantzsch 1,4-二氢吡啶作为还原剂，在无溶剂条件下通过微波辅助的三组分反应合成5-烷基化的巴比妥酸和3-烷基化的吲哚
3. Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step multicomponent reaction followed by a S-alkylation [J] . Li M, Zuo ZQ, Wen LR, Journal of combinatorial chemistry . 2008,第3期

机译：微波辅助组合合成一锅两步多组分反应后进行S-烷基化的六取代的1,4-二氢吡啶骨架
4. Microwave-Assisted One-Pot Multicomponent Synthesis of 1,4-Dihydropyridine Derivatives using Nanochitosan [C] . D. Febriantini, A. H. Cahyana, R. T. Yunarti, International Symposium on Current Progress in Mathematics and Sciences . 2019

机译：使用纳米分组的微波辅助1罐多组分合成1,4-二氢吡啶衍生物
5. 1,4-Dipole forming photoreactions of alpha-trimethylsilyl and alpha-tributylstannyl substituted alpha-ketoamides, and, Mechanistic studies of photomacrocyclization reactions and their application in crown ether synthesis and fluorescence sensing of metal cations. [D] . Wang, Runtang. 2005

机译：α-三甲基甲硅烷基和α-三丁基锡烷基取代的α-酮酰胺的1，4-偶极形成光反应，以及光宏环化反应的机理研究及其在冠醚合成和金属阳离子荧光传感中的应用。
6. Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-14-dihydropyridine-3-carboxylate and 4-Arylsubstituted-47-dihydrofuro34-bpyridine-25(1H3H)-dione [O] . Hortensia Rodríguez, Osnieski Martin, Margarita Suarez, 2011

机译：制备与二氢吡啶有关的N-杂环的生态友好方法：微波辅助合成4-芳基取代的6-氯-5-甲酰基-2-甲基-14-二氢吡啶-3-羧酸酯和4-芳基取代的4-烷基7-二氢呋喃34-b吡啶-25（1H3H）-二酮
7. Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione [O] . Fernando Albericio, Nazario Martín, Hortensia Rodríguez, 2011

机译：制备与二氢吡啶相关的N-杂环的环保方法：微波辅助合成4-芳基取代的-6-氯-5-甲酰基-2-甲基-1,4-二氢吡啶-3-羧酸烷基酯和4-芳基取代-4 ，7-二氢呋喃并[3,4-b]吡啶-2,5（1H，3H） - 二酮

Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to Amlodipine

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