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Droplet-based electrospray ionization mass spectrometry for qualitative and quantitative analysis

机译：基于液滴的电喷雾电离质谱法，用于定性和定量分析

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Mass spectrometry (MS) is a rapid and sensitive analytical tool that can provide information such as molecular weight and structure.~([1,2]) One of the fast growing fields in MS in the beginning of this century is the development of ion sources at atmospheric pressure. Speed, simplicity and minimal sample preparation are the main characteristics of these recently developed ion sources at open air.~([3-21]) Most ion sources are mainly used in qualitative MS analysis. However, quantitative analysis can provide important information in different analyses, such as in the determination of the level of specific species in natural products~([22,23]) and the concentration of disease-related biomarkers in biological fluids.~([24,25]) Conventionally, chromatography combined with MS can provide reliable quantitative analysis. Nevertheless, newly developed ion sources could be potentially used in quantitative analysis,~([15,26-31]) such as the use of laser electrospray MS in the quantitative analysis of mixtures of small molecules.~([26]) Laser diode thermal desorption combined with atmospheric pressure chemical ionization was also used to quantify sulfonamide residues in dairy milk.~([27]) Paper spray has been demonstrated its potential in the quantitative analysis of abused drugs.~([28]) In addition, direct analysis in real-time ionization MS for the quantification of drugs in biological matrixes was also successfully demonstrated.~([31])
机译：质谱（MS）是一种快速灵敏的分析工具，可以提供诸如分子量和结构等信息。〜（[1,2]）离子的发展是本世纪初MS领域快速发展的领域之一。源在大气压下。速度，简便和样品制备量最少是这些新近开发的露天离子源的主要特征。〜[[3-21]）大多数离子源主要用于定性MS分析。然而，定量分析可以在不同的分析中提供重要的信息，例如确定天然产物中特定物种的水平〜[[22,23]）和生物体液中疾病相关生物标志物的浓度。〜[24 ，25]）常规上，色谱与质谱联用可以提供可靠的定量分析。尽管如此，新开发的离子源仍可能用于定量分析，[（15,26-31）），例如在小分子混合物的定量分析中使用激光电喷雾质谱仪。[[26]）激光二极管热脱附与大气压化学电离相结合也可用于定量测定牛奶中的磺酰胺残留量。〜（[27]）已证明纸喷雾剂在滥用药物的定量分析中具有潜力。〜（[28]）此外，直接还成功地证明了实时电离质谱法对生物基质中药物的定量分析。〜（[31]）

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