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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >COMPUTER SIMULATION OF THE TEMPERATURE- AND HYDRATION-DEPENDENT LATERAL DIFFUSION OF PHOSPHATIDYLCHOLINE IN LIPID BILAYERS
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COMPUTER SIMULATION OF THE TEMPERATURE- AND HYDRATION-DEPENDENT LATERAL DIFFUSION OF PHOSPHATIDYLCHOLINE IN LIPID BILAYERS

机译:脂质双层中磷脂酰胆碱的温度和水合作用侧向扩散的计算机模拟

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摘要

A lattice model of a lipid bilayer near the so-called main phase transition between the liquid crystalline (L(alpha)) and the gel (L(beta)) phase is presented. It is based on a two-state model, Jump dynamics are defined for the lattice molecules to simulate lateral diffusion. The temperature and hydration dependence of the lateral diffusion coefficients of the model are calculated for the L(alpha) phase using Monte Carlo simulation techniques. The results obtained allow the estimation of the hydration dependent part of the lateral diffusion activation energy by thermodynamical quantities. We compare these results with measured activation energies of dipalmitoylphosphatidylcholine (DPPC) and propose a model to describe the total lateral diffusion activation energy of such systems. [References: 39]
机译:提出了在液晶(Lα)和凝胶(Lβ)相之间所谓的主相变附近的脂质双层的晶格模型。它基于二态模型,为晶格分子定义了跳跃动力学,以模拟横向扩散。使用蒙特卡洛模拟技术为Lα相计算模型的横向扩散系数的温度和水合作用依赖性。获得的结果允许通过热力学量来估计横向扩散活化能的水合依赖性部分。我们将这些结果与测得的二棕榈酰磷脂酰胆碱(DPPC)的活化能进行比较,并提出一个模型来描述此类系统的总横向扩散活化能。 [参考:39]

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