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首页> 外文期刊>Journal of lower genital tract disease. >Cervical Intraepithelial Neoplasia 2, 3 in Pregnancy: Time to Consider Loop Cone Excision in the First Trimester of Pregnancy?
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Cervical Intraepithelial Neoplasia 2, 3 in Pregnancy: Time to Consider Loop Cone Excision in the First Trimester of Pregnancy?

机译：宫颈上皮内瘤样变2、3在妊娠中：在妊娠的头三个月要考虑进行Loop锥切除术了吗？

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Objectives. To report the outcome of patients diagnosed with cervical intraepithelial neoplasia 2, 3 (CIN 2, 3) during pregnancy, who were treated by large loop excision of the transformation zone (LLETZ) in the first trimester or were followed up conservatively and treated after delivery.Methods. Patients diagnosed with CIN 2, 3 during pregnancy who were treated with LLETZ or were conservatively followed up were included. Complications of the LLETZ, pathologic results, and pregnancy outcome of both groups were examined after delivery.Results. Thirty-one patients were included in the study. Eighteen were conservatively followed up and 13 underwent LLETZ during the first 14 weeks of pregnancy. Four patients (12.9%) in the study group were diagnosed with invasive cervical cancer. From women who underwent LLETZ, 9 patients continued their pregnancy, 7 of which had term normal deliveries and 2 had late preterm deliveries. No complications of severe bleeding or miscarriage were reported in any of the treated patients.Conclusions. Large loop excision of the transformation zone procedure in the first trimester of pregnancy is a safeprocedure, with the advantage of treating definitively CIN 2, 3 lesions and preventing the devastating consequences of undiagnosed cervical cancer. We suggest that LLETZ should be performed more liberally in the first trimester of pregnancy.
机译：目标。报告妊娠期间被诊断为宫颈上皮内瘤样变2、3（CIN 2、3）的患者的结局，这些患者在妊娠前三个月经大环切除转化区（LLETZ）进行了治疗，或者接受了保守的随访并在分娩后进行了治疗。方法。包括在妊娠期间被诊断为CIN 2、3的患者，这些患者接受LLETZ治疗或保守随访。分娩后检查两组的LLETZ并发症，病理结果和妊娠结局。这项研究包括了31名患者。保守地随访了18例，在怀孕的前14周中对13例进行了LLETZ。研究组中有四名患者（12.9％）被诊断为浸润性宫颈癌。从接受LLETZ治疗的女性中，有9例患者继续妊娠，其中7例足月分娩，2例早产。在任何接受治疗的患者中均未报告严重出血或流产的并发症。妊娠前三个月大面积切除转化区手术是一种安全的方法，其优点是可以明确治疗CIN 2、3病变并防止未诊断的宫颈癌的毁灭性后果。我们建议在怀孕的前三个月更宽松地进行LLETZ。

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