• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of magnetic resonance >Simultaneous detection of resolved glutamate, glutamine, and gamma-aminobutyric acid at 4 T
【24h】

Simultaneous detection of resolved glutamate, glutamine, and gamma-aminobutyric acid at 4 T

机译：同时检测4 T时解析出的谷氨酸，谷氨酰胺和γ-氨基丁酸

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new approach is introduced to simultaneously detect resolved glutamate (Gin), glutamine (Gin), and gamma-aminobutyric acid (GABA) using a standard STEAM localization pulse sequence with the optimized sequence timing parameters. This approach exploits the dependence of the STEAM spectra of the strongly coupled spin systems of Gin, Gin, and GABA on the echo time TE and the mixing time TM at 4 T to find an optimized sequence parameter set, i.e., {TE, TM}, where the outer-wings of the Gin C4 multiplet resonances around 2.35 ppm, the Gin C4 multiplet resonances around 2.45 ppm, and the GABA C2 multiplet resonance around 2.28 ppm are significantly suppressed and the three resonances become virtual singlets simultaneously and thus resolved. Spectral simulation and optimization were conducted to find the optimized sequence parameters, and phantom and in vivo experiments (on normal human brains, one patient with traumatic brain injury, and one patient with brain tumor) were carried out for verification. The results have demonstrated that the Gin, Glu, and GABA signals at 2.2-2.5 ppm can be well resolved using a standard STEAM sequence with the optimized sequence timing parameters around {82 ms, 48 ms} at 4 T, while the other main metabolites, such as N-acetyl aspartate (NAA), choline (Who), and creatine (tCr), are still preserved in the same spectrum. The technique can be easily implemented and should prove to be a useful tool for the basic and clinical studies associated with metabolism of Gin, Gin, and/or GABA. (C) 2006 Elsevier Inc. All rights reserved.
机译：引入了一种新方法，该方法使用具有优化序列定时参数的标准STEAM定位脉冲序列，同时检测分解的谷氨酸（Gin），谷氨酰胺（Gin）和γ-氨基丁酸（GABA）。该方法利用了Gin，Gin和GABA的强耦合自旋系统的STEAM光谱对4 T处的回波时间TE和混合时间TM的依赖性，以找到优化的序列参数集，即{TE，TM} ，其中Gin C4多重共振的外翼在2.35 ppm附近，Gin C4多重共振在2.45 ppm附近和GABA C2多重共振在2.28 ppm附近被显着抑制，并且三个共振同时变为虚拟单重态，因此得以解决。进行光谱模拟和优化以找到优化的序列参数，并进行了幻像和体内实验（在正常人脑上，对一名颅脑外伤患者和一名脑肿瘤患者）进行了验证。结果表明，使用标准STEAM序列可以很好地分辨2.2-2.5 ppm的Gin，Glu和GABA信号，并在4 T时以{82 ms，48 ms}左右的优化序列时序参数进行优化，而其他主要代谢产物，例如N-乙酰天门冬氨酸（NAA），胆碱（Who）和肌酸（tCr），仍保留在同一光谱中。该技术易于实施，应被证明是与Gin，Gin和/或GABA代谢相关的基础和临床研究的有用工具。 （C）2006 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号