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首页> 外文期刊>Journal of Medical Virology >A Genetic Variant In MicroRNA-122 Regulatory Region.Confers Risk for Chronic Hepatitis B Virus Infection and Hepatocellular Carcinoma In Han Chinese
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A Genetic Variant In MicroRNA-122 Regulatory Region.Confers Risk for Chronic Hepatitis B Virus Infection and Hepatocellular Carcinoma In Han Chinese

机译：MicroRNA-122调控区的一种遗传变异。汉族人群患有慢性乙型肝炎病毒感染和肝细胞癌的风险

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摘要

miR-122 plays a vital role in the development of chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Based on data from the Encyclopedia of DNA Elements (ENCODE), two single nucleotide polymorphisms (SNPs), rs4309483 and rs45Q3880, were identified in the upstream regulatory region of miR-122. A case-control study consisting of 1,300 HBV-positive HCC cases, 1,344 HBV carriers, and 1,344 persons who cleared HBV naturally was carried out to test the association between the two SNPs and the risk for chronic HBV infection and HCC. The CA/AA genotypes of rs4309483 were associated with significantly increased risk for HCC [adjusted odds ratio (OR) = 1.21, 95% confidence intervals (Cls) = 1.02-1.43, P= 0.025] compared with HBV carriers, but decreased risk for chronic HBV infection (adjusted OR = 0.82, 95% Cls = 0.70-0.97, P=0.017) compared with persons who cleared HBV naturally. The genotype-expression correlation between rs4309483 and the expression of primary or mature miR-122 expression was investigated in 29 pairs of HBV positive HCC and noncancerous liver tissues. In noncancer-ous liver tissues, subjects carrying the CA genotype exhibited significantly lower expression level of pri-miR-122 than those carrying the CC genotype. In addition, positive or inverse correlation between the expression levels of pri-miR-122 and mature miR-122 were observed in HCC tissues or noncancerous tissues, respectively. These findings indicate that the C to A base change of rs4309483 may alter the expression of miR-122, thus providing protective effect from chronic HBV infection but an increased risk for HCC in HBV carriers.
机译：miR-122在慢性乙型肝炎病毒（HBV）感染和肝细胞癌（HCC）的发展中起着至关重要的作用。根据来自DNA元素百科全书（ENCODE）的数据，在miR-122的上游调控区中发现了两个单核苷酸多态性（SNP），即rs4309483和rs45Q3880。进行了一项由1300例HBV阳性HCC病例，1,344例HBV携带者和1,344例自然清除HBV的患者组成的病例对照研究，以测试这两个SNP与慢性HBV感染和HCC风险之间的关联。与HBV携带者相比，rs4309483的CA / AA基因型与HCC的风险显着增加[调整比值比（OR）= 1.21，95％置信区间（Cls）= 1.02-1.43，P = 0.025]与自然清除HBV的人相比，慢性HBV感染（调整后的OR = 0.82，95％Cls = 0.70-0.97，P = 0.017）。在29对HBV阳性HCC和非癌性肝组织中研究了rs4309483与初级或成熟miR-122表达之间的基因型表达相关性。在非癌性肝组织中，携带CA基因型的受试者的pri-miR-122表达水平明显低于携带CC基因型的受试者。另外，分别在HCC组织或非癌组织中观察到pri-miR-122和成熟miR-122的表达水平之间的正相关或逆相关。这些发现表明，rs4309483的C到A碱基改变可能会改变miR-122的表达，从而提供对慢性HBV感染的保护作用，但会增加HBV携带者发生HCC的风险。

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