Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents

Ugo Chiacchio; Antonio Rescifina; Daniela Iannazzo

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Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents

机译：磷酸化的碳环2'-Oxa-3'-氮杂核苷作为新的抗逆转录病毒药物

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Phosphonated carbocyclic 2'-oxa-3'-azanucleosides have been synthesized and tested for their antiretroviral activity. The obtained results have shown that some of the compounds were as powerful as azydothymidine in inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virus type 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/ lymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by human retroviruses.

机译：已合成了膦酸酯化的碳环2'-oxa-3'-氮杂核苷，并对其抗逆转录病毒活性进行了测试。获得的结果表明，某些化合物在抑制人逆转录病毒T细胞白血病/淋巴病毒1型的逆转录酶活性以及保护人外周血单核细胞免受人逆转录病毒T细胞白血病/ 1型淋巴病毒在体外传播。这些数据表明，磷酸化的碳环2'-oxa-3'-氮杂核苷具有有效抵抗人类逆转录病毒引起的感染的必要要求。

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《Journal of Medicinal Chemistry》 |2007年第15期|共4页
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Ugo Chiacchio; Antonio Rescifina; Daniela Iannazzo;
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中图分类药学;
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1. Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents [J] . Ugo Chiacchio, Antonio Rescifina, Daniela Iannazzo Journal of Medicinal Chemistry . 2007,第15期

机译：磷酸化的碳环2'-Oxa-3'-氮杂核苷作为新的抗逆转录病毒药物
2. Enantiomerically Pure Phosphonated Carbocyclic 2 '-Oxa-3 '-Azanucleosides: Synthesis and Biological Evaluation [J] . Romeo Roberto, Carnovale Caterina, Giofre Salvatore V., Molecules . 2014,第9期

机译：对映体纯的膦酰基碳环的2'-Oxa-3'-氮杂核苷：合成和生物学评价。
3. Enantiomerically Pure Phosphonated Carbocyclic 2'-Oxa-3'-Azanucleosides: Synthesis and Biological Evaluation [J] . Beatrice Macchi, Caterina Carnovale, Claudia Sanfilippo, Molecules . 2014,第9期

机译：对映体纯的膦酰基碳环的2'-Oxa-3'-氮杂核苷：合成及生物学评价。
4. Speciation and Chemical Reactions of Phosphonate Chelating Agents in Aqueous Media [C] . A. T. Stone, M. A. Knight, B. Nowack ACS national meeting . 2002

机译：含水介质中膦酸盐螯合剂的形态和化学反应
5. Purine and pyrimidine carbocyclic nucleosides as antiviral agents. [D] . Bailey, Elaine LeCreurer. 2004

机译：嘌呤和嘧啶碳环核苷可作为抗病毒药。
6. Effect of Phosphonated Carbocyclic 2′-Oxa-3′-Aza-Nucleoside on Human T-Cell Leukemia Virus Type 1 Infection In Vitro [O] . Emanuela Balestrieri, Claudia Matteucci, Arianna Ascolani, 2008

机译：磷酸化的碳环2-Oxa-3-氮杂-核苷对人T细胞白血病病毒1型体外感染的影响
7. Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents [O] . Chiacchio U, Rescifina A, Iannazzo D, 2007

机译：磷酸化的碳环2'-Oxa-3'-氮杂核苷作为新的抗逆转录病毒药物
8. Quantum Chemical Study of the Phosphite-Phosphonate Tautomerization: Applications to bis(2-Ethylhexyl) Phosphonate (BIS) and Other Simulants for Chemical Warfare Agents [R] . White, W. E. 2002

机译：亚磷酸酯 - 膦酸酯互变异构化的量子化学研究：双（2-乙基己基）膦酸酯（BIs）和化学战剂的其他模拟物的应用

Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents

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