Potent inhibitors of the Qi site of the mitochondrial respiration complex III

Bolgunas S; Clark DA; Hanna WS; Mauvais PA; Pember SO

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Potent inhibitors of the Qi site of the mitochondrial respiration complex III

机译：线粒体呼吸复合体III位点的有效抑制剂

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A series of azole-fused salicylamides were prepared as analogues of antimycin and assayed for activity at complex III of the mitochondrial respiratory chain. The activity of these compounds approached that of antimycin in inhibitory potency and some showed growth reduction of Septoria nodorum in vitro. Compound 8a was shown to bind at the Qi site of complex III by red-shift titration of the bc(1) complex.

机译：制备了一系列与唑类融合的水杨酰胺作为抗霉素类似物，并测定了其在线粒体呼吸链复合物III上的活性。这些化合物的活性在抑制力上接近抗霉素的活性，并且一些化合物在体外显示出诺氏夜蛾的生长减少。化合物8a通过bc（1）络合物的红移滴定显示在络合物III的Qi位点结合。

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《Journal of Medicinal Chemistry》 |2006年第15期|共5页
作者
Bolgunas S; Clark DA; Hanna WS; Mauvais PA; Pember SO;
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正文语种 eng
中图分类药学;
关键词
BC(1) COMPLEX; CYTOCHROME BC(1); ANTIMYCIN; FUNGICIDE; STROBILURINS; MOLECULE; MODE; ACID;

机译：BC（1）络合物;细胞色素BC（1）;抗霉素;杀菌剂;链霉菌素;分子;模式;酸;

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1. Potent inhibitors of the Qi site of the mitochondrial respiration complex III [J] . Bolgunas S, Clark DA, Hanna WS, Journal of Medicinal Chemistry . 2006,第15期

机译：线粒体呼吸复合体III位点的有效抑制剂
2. Ametoctradin is a Potent Q(o) Site Inhibitor of the Mitochondrial Respiration Complex III (vol 63, pg 3377, 2015) [J] . Zhu Xiaolei, Zhang Mengmeng, Liu Jingjing, Journal of Agricultural and Food Chemistry . 2015,第45期

机译：Ametoctradin是线粒体呼吸复合物III的有效Q（o）部位抑制剂（vol 63，pg 3377，2015）
3. Ametoctradin is a Potent Q(o) Site Inhibitor of the Mitochondria! Respiration Complex III [J] . Zhu Xiaolei, Zhang Mengmeng, Liu Jingjing, Journal of Agricultural and Food Chemistry . 2015,第13期

机译：Ametoctradin是线粒体的强Q（o）部位抑制剂！呼吸复合物III
4. Profiling mitochondrial complex I inhibitors by combining mitochondrial morphological features and maximum common chemical substructures [C] . Lin Chung-Chih, Peng Jyh-Ying, Yi-Hsuan Tseng, 2014 IEEE International Symposium on Bioelectronics and Bioinformatics . 2014

机译：结合线粒体形态特征和最大的常见化学亚结构分析线粒体复合物I抑制剂
5. Cyclosporine A inhibits skeletal muscle mitochondrial respiration. [D] . Hokanson, James Francis. 1999

机译：环孢菌素A抑制骨骼肌线粒体呼吸。
6. 3-NITROPROPIONIC ACID IS A SUICIDE INHIBITOR OF MITOCHONDRIAL RESPIRATION THAT UPON OXIDATION BY COMPLEX II FORMS A COVALENT ADDUCT WITH A CATALYTIC-BASE ARGININE IN THE ACTIVE SITE OF THE ENZYME [O] . Li-shar Huang, Gang Sun, David Cobessi, -1

机译：3-硝基丙酸是线粒体呼吸的自杀抑制剂经络合物II氧化后在酶的活性部位与催化型精氨酸形成共价产物
7. Different oxidants and PKC isozymes mediate the opposite effect of inhibition of Qi and Qo site of mitochondrial complex III on calcium currents in rat cortical neurons [O] . Wu Pei-Ying, Lai Bin, Dong Yi, 2010

机译：不同的氧化剂和PKC同工酶介导线粒体复合物III的Qi和Qo位点抑制对大鼠皮质神经元钙电流的相反作用

Potent inhibitors of the Qi site of the mitochondrial respiration complex III

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