Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

Baker SJ; Zhang YK; Akama T; Lau A; Zhou H; Hernandez V; Mao WM; Alley MRK; Sanders V; Plattner JJ

首页> 外文期刊>Journal of Medicinal Chemistry >Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

【24h】

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

机译：发现一种新型的含硼抗真菌剂5-氟-1,3-二氢-1-羟基-2,1-苯并恶唑硼烷（AN2690），可用于治疗甲癣

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

机译：为了更有效地治疗甲癣，脚趾和指甲的真菌感染，进行了结构活性关系研究，结果发现了含硼的小分子5-氟-1,3-二氢-1-羟基- 2,1-苯并硼硼烷（AN2690），目前正在进行甲癣局部治疗的临床试验。

著录项

来源
《Journal of Medicinal Chemistry》 |2006年第15期|共4页
作者
Baker SJ; Zhang YK; Akama T; Lau A; Zhou H; Hernandez V; Mao WM; Alley MRK; Sanders V; Plattner JJ;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
STRATEGIES; RECURRENCE; EPIDEMIOLOGY; PREVALENCE;

机译：策略;复发;流行病学;流行;

相似文献

外文文献
中文文献
专利

1. Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis [J] . Baker SJ, Zhang YK, Akama T, Journal of Medicinal Chemistry . 2006,第15期

机译：发现一种新型的含硼抗真菌剂5-氟-1,3-二氢-1-羟基-2,1-苯并恶唑硼烷（AN2690），可用于治疗甲癣
2. Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles [J] . Zhang Yong-Kang, Plattner Jacob J., Easom Eric E., Journal of Medicinal Chemistry . 2015,第13期

机译：苯并沙硼烷抗疟剂。第4部分。有效的6-（2-（烷氧基羰基）吡嗪基-5-氧基）-1,3-二氢-1-羟基-2,1-苯并恶硼烷的发现
3. Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles [J] . ZhangY.-K., PlattnerJ.J., FreundY.R., Bioorganic and Medicinal Chemistry Letters . 2012,第3期

机译：苯并氧杂硼酸抗疟剂。第2部分：发现氟取代的7-（2-羧乙基）-1,3-二氢-1-羟基-2,1-苯并恶唑
4. Using bioinformatic technique to discovery Huangqin and Lianqiao combination as a potential new drus for treatment acne [C] . Jiang Chunyan, Li Jian, Tan Yong, IEEE International Conference on Bioinformatics and Biomedicine . 2013

机译：利用生物信息学技术发现黄Huang和莲桥组合是治疗痤疮的潜在新药
5. Multisubstrate analog inhibitors of glucosamine synthase as potential antifungal agents. [D] . Chittur, Sridar Venkitakrishnan. 1996

机译：葡糖胺合酶的多底物类似物抑制剂作为潜在的抗真菌剂。
6. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213 a Novel Onychomycosis Therapy Candidate [O] . Derry K. Mercer, Colin S. Stewart, Lorna Miller, 2019

机译：评估抗真菌药物对皮肤癣菌的治疗潜力的改进方法及其在新型甲癣治疗候选药物NP213研发中的应用
7. Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis [O] . -1

机译：发现含有新的含硼的抗真菌剂，5-氟-1,3-二氢-1-羟基-2,1-苯并氧基（AN2690），潜在治疗甲癣

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

摘要

著录项

相似文献

相关主题

期刊订阅