Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

Posner GH; Ploypradith P; Parker MH; ODowd H; Woo SH; Northrop J; Krasavin M; Dolan P; Kensler TW; Xie S; Shapiro TA

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Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

机译：青蒿素衍生的化学作用强的三恶烷二聚体的抗疟，抗增殖和抗肿瘤活性。

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Nine C-10 non-acetal derivatives of the natural trioxane artemisinin (1) were prepared as dimers using some novel chemistry. As designed, each dimer was stable chemically. C-10 Olefinic dimers 7 and C-10 saturated dimers 8-13 all showed good to excellent antimalarial and antiproliferative activities in vitro. Dimers 8, 10, and 12 were especially potent and selective at inhibiting growth of some human cancer cell lines in the NCI in vitro 60-cell line assay.

机译：天然三恶烷青蒿素（1）的九种C-10非缩醛衍生物使用一些新化学方法制备为二聚体。按照设计，每个二聚体在化学上是稳定的。 C-10烯烃二聚体7和C-10饱和二聚体8-13在体外均表现出良好的抗疟和抗增殖活性。在NCI体外60细胞株测定中，二聚体8、10和12在抑制某些人类癌细胞系生长方面特别有效且具有选择性。

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来源
《Journal of Medicinal Chemistry》 |1999年第21期|共6页
作者
Posner GH; Ploypradith P; Parker MH; ODowd H; Woo SH; Northrop J; Krasavin M; Dolan P; Kensler TW; Xie S; Shapiro TA;
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正文语种 eng
中图分类药学;
关键词
Antimalarials; Antineoplastic Agents; Lactones; Sesquiterpenes; artemisin; 抗疟药; 抗肿瘤药; 内酯类; 倍半萜类;

机译：Antimalarials;Antineoplastic Agents;Lactones;Sesquiterpenes;artemisin;抗疟药;抗肿瘤药;内酯类;倍半萜类;

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1. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. [J] . Posner GH, Ploypradith P, Parker MH, Journal of Medicinal Chemistry . 1999,第21期

机译：青蒿素衍生的化学作用强的三恶烷二聚体的抗疟，抗增殖和抗肿瘤活性。
2. New chemical and biological aspects of artemisinin-derived trioxane dimers. [J] . Posner GaryH, Northrop John, Paik IkHyeon, Bioorganic and medicinal chemistry . 2002,第1期

机译：青蒿素衍生的三恶烷二聚体的新化学和生物学方面。
3. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity [J] . Paik IH, Xie SJ, Shapiro TA, Journal of Medicinal Chemistry . 2006,第9期

机译：第二代口服活性，抗疟疾，青蒿素衍生的三恶烷二聚体，具有较高的稳定性，功效和抗癌活性
4. Enhanced tumor targeting and antitumor activity of xanthine oxidase by chemical conjugation with peg [C] . T. Sawa, J. Wu, T. Akaike, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：黄嘌呤氧化酶与PEG的化学缀合可增强肿瘤靶向性和黄嘌呤氧化酶的抗肿瘤活性
5. Orally active and robust Artemisinin-derived trioxanes: Antimalarial, antiproliferative, and anticancer efficacies. [D] . Paik, Ik-Hyeon. 2006

机译：口服活性强健的青蒿素衍生的三恶烷：抗疟疾，抗增殖和抗癌功效。
6. Synthesis and Antimalarial Efficacy of Two-Carbon Linked Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs [O] . Bryan T. Mott, Abhai Tripathi, Maxime A. Siegler, -1

机译：二碳的合成和抗疟疾功效挂钩青蒿素衍生三聚甲醛二聚体与已知抗疟药
7. Antimalarial chemotherapy: Orally curative artemisinin-derived trioxane dimer esters [O] . Ryan C. Conyers, Jennifer R. Mazzone, Abhai K. Tripathi, 2015

机译：抗疟疗法：口服养殖青蒿素衍生的三恶烷二聚体酯

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

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