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首页> 外文期刊>The Tohoku Journal of Experimental Medicine >Cardiac autonomic functions are altered in patients with acute leukemia, assessed by heart rate variability.
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Cardiac autonomic functions are altered in patients with acute leukemia, assessed by heart rate variability.

机译：通过心率变异性评估，急性白血病患者的心脏自主神经功能发生改变。

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摘要

Acute leukemia is one of the leading malignancies worldwide. Although neuropathy was reported as one of the complications of leukemia, there is a little data about the autonomic involvement. This study was designed to investigate the cardiac autonomic disturbances in acute leukemias by using time-domain indices of heart rate variability (HRV). Newly diagnosed 36 patients with acute leukemia (14 acute lymphoblastic leukemia and 22 acute myeloblastic leukemia) and gender- and age-matched 32 healthy subjects as controls were enrolled in this study. The diagnosis of leukemia was established by whole blood count, peripheral smears and bone marrow aspirations. In order to rule out the effect of any medication on HRV, the patients were selected from those who had not received any antineoplastic agent yet. For assessing the cardiac autonomic functions, HRV obtained from 24-hr Holter monitor recordings was used. The age, gender and serum ferritin levels were similar, while hemoglobin levels were lower in the leukemia group. The comparison of the leukemia group and control group revealed that HRV decreased in patients with acute leukemia, which reflects sympathetic dominance in acute leukemia. This is the first study that shows altered cardiac autonomic functions in patients with acute leukemias who are not on any therapeutical intervention. The altered cardiac autonomic functions may be a sign of paraneoplastic neuropathy in patients with acute leukemia.
机译：急性白血病是全球主要的恶性肿瘤之一。尽管神经病被报告为白血病的并发症之一，但有关自主神经受累的数据却很少。本研究旨在通过使用心率变异性（HRV）的时域指标来调查急性白血病中的心脏自主神经功能紊乱。本研究纳入了新诊断的36例急性白血病（14例急性淋巴细胞白血病和22例急性粒细胞白血病）以及性别和年龄相匹配的32例健康受试者作为对照。白血病的诊断是通过全血细胞计数，外周涂片检查和骨髓穿刺确定的。为了排除任何药物对HRV的影响，从尚未接受任何抗肿瘤药的患者中选择患者。为了评估心脏自主功能，使用了从24小时动态心电图监测记录中获得的HRV。白血病组的年龄，性别和血清铁蛋白水平相似，而血红蛋白水平较低。白血病组和对照组的比较显示，急性白血病患者的HRV下降，这反映了急性白血病的交感优势。这是第一项显示未接受任何治疗干预的急性白血病患者心脏自主神经功能改变的研究。心脏自主神经功能的改变可能是急性白血病患者副肿瘤性神经病变的征兆。

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