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首页> 外文期刊>Journal of neuro-oncology. >HMME-based PDT restores expression and function of transporter associated with antigen processing 1 (TAP1) and surface presentation of MHC class I antigen in human glioma.
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HMME-based PDT restores expression and function of transporter associated with antigen processing 1 (TAP1) and surface presentation of MHC class I antigen in human glioma.

机译：基于HMME的PDT可恢复与人类神经胶质瘤中抗原加工1（TAP1）和MHC I类抗原的表面呈递相关的转运蛋白的表达和功能。

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Numerous studies have established that photodynamic therapy (PDT) can trigger tumor-specific immunity and cancer cell immunogenicity, both of which play a critical role in the long-term control of oncogenesis; however, the underlying mechanisms are largely unexplained. Deficiency of the transporter associated with antigen processing 1 (TAP1) has been observed in a variety of tumors, and the question has been raised whether the restoration of TAP1 could facilitate the activation of antitumor immunity. To elucidate the mechanisms underlying PDT-induced immunopotentiation, we examined the hypothesis that upregulating TAP1 via PDT may contribute to enhancement of antitumor immunity and cancer cell immunogenicity. In this study, we investigated the effects of PDT on the expression and function of TAP1 in glioma cells. We found that HMME-based PDT restored TAP1 expression in a rapid and transient manner. Furthermore, the newly synthesized TAP1 protein was capable of potentiating the activity of transporting antigen peptides. As a result, restoration of the expression and function of TAP1 translated into augmenting the presentation of surface MHC class I molecules. Overall, our data indicate that PDT enables glioma cells to recover both the expression of functional TAP1 and the presentation of surface MHC class I antigens, which are processes that may enhance antitumor immunity after PDT. These findings may have implications for PDT and provide new insights into the mechanisms underlying PDT-induced immunopotentiation.
机译：大量研究表明，光动力疗法（PDT）可以触发肿瘤特异性免疫力和癌细胞免疫原性，这两者在肿瘤形成的长期控制中起着至关重要的作用。但是，基本机制尚无法解释。已经在多种肿瘤中观察到了与抗原加工1（TAP1）相关的转运蛋白的缺乏，并提出了一个问题，即TAP1的恢复是否可以促进抗肿瘤免疫的激活。为了阐明PDT诱导的免疫增强的潜在机制，我们检查了以下假设：通过PDT上调TAP1可能有助于增强抗肿瘤免疫力和癌细胞免疫原性。在这项研究中，我们研究了PDT对神经胶质瘤细胞中TAP1表达和功能的影响。我们发现基于HMME的PDT以快速而短暂的方式恢复了TAP1表达。此外，新合成的TAP1蛋白能够增强转运抗原肽的活性。结果，TAP1表达和功能的恢复转化为增加了表面MHC I类分子的表达。总体而言，我们的数据表明，PDT使神经胶质瘤细胞恢复功能性TAP1的表达和表面MHC I类抗原的呈递，这些过程可能会增强PDT后的抗肿瘤免疫力。这些发现可能对PDT具有影响，并为PDT诱导的免疫增强的潜在机制提供了新的见解。

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