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首页> 外文期刊>Journal of Molecular Biology >Fitness increase of memory genomes in a viral quasispecies.
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Fitness increase of memory genomes in a viral quasispecies.

机译：病毒准种中记忆基因组的适应性增加。

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摘要

Viral quasispecies may contain a subset of minority genomes that reflect those genomic sequences that were dominant at an early phase of quasispecies evolution. Such minority genomes are referred to as memory in viral quasispecies. A memory marker previously characterized in foot-and-mouth disease virus (FMDV) is an internal oligoadenylate tract of variable length that became dominant upon serial plaque-to-plaque transfers of FMDV clones. During large population passages, genomes with internal oligoadenylate were outcompeted by wild-type revertants but remained in the mutant spectra as memory genomes. Here, we report a quantification of relative fitness of several FMDV clones, harboring internal oligoadenylate tracts of different length, and that were retrieved at early or late times (passage number) after implementation of memory. The results show that for any given length range of the oligoadenylate, maintenance in memory resulted in an increase in relative fitness, comparable to the increase undergone by the entire population. The fitness increase is in agreement with the Red Queen hypothesis, and implies a replicative memory mechanism. Thus, permanence of memory genomes may be a source of high fitness variants despite their initial low fitness, and despite having remained hidden in mutant spectra. This reinforces the interest of diagnosing minority genomes during chronic human and animal viral infections.
机译：病毒准种可能包含少数基因组的子集，这些子集反映了在准种进化的早期占主导地位的那些基因组序列。这样的少数基因组被称为病毒准种的记忆。先前以口蹄疫病毒（FMDV）为特征的记忆标记是可变长度的内部寡聚腺苷酸片段，在FMDV克隆从噬菌斑到噬菌斑的连续转移中占主导地位。在大量种群传代过程中，带有内部寡聚腺苷酸的基因组被野生型回复子所竞争，但保留在突变体谱中作为记忆基因组。在这里，我们报告了几个FMDV克隆的相对适合度的量化，这些克隆带有不同长度的内部寡聚腺苷酸片段，并且在实现内存后的早期或晚期（通道数）中检索到。结果表明，对于任何给定长度范围的寡聚腺苷酸，记忆力的维持都会导致相对适应性的提高，与整个人群所经历的提高相当。适应度的增加与Red Queen假说是一致的，并且暗示了复制记忆机制。因此，记忆基因组的持久性可能是高适应性变异的来源，尽管它们最初的适应性很低，尽管仍然隐藏在突变谱中。这增强了在慢性人类和动物病毒感染期间诊断少数基因组的兴趣。

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