Location of the binding site of the mannose-specific lectin comitin on F-actin

Fulgenzi G.; Granata AL.; Corsi A.; Fucini P.; Noegel AA. Kent HM.; Stewart M.; Graciotti L.

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Location of the binding site of the mannose-specific lectin comitin on F-actin

机译：甘露糖特异性凝集素commitin在F-肌动蛋白上的结合位点的位置

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We have used electron microscopy and computer image processing to produce a three-dimensional reconstruction of F-actin filaments decorated with the putative lectin and actin-binding protein comitin. These reconstructions show that comitin binds to F-actin at high radius primarily to actin subdomain 1. This location is distinctly different from the binding site on F-actin for other actin bundling proteins, such as members of the a-actinin family, and may result from the positively charged comitin interacting with negatively charged sites near the actin N terminus in subdomain 1. The location of the comitin binding site and its restriction to subdomain 1 on a single actin monomer is consistent with comitin's having a function distinct from other actin-binding proteins and, for example, would enable comitin to link bundled actin filaments to the Golgi. (C) 1998 Academic Press. [References: 38]

机译：我们已经使用电子显微镜和计算机图像处理来产生F-肌动蛋白丝的三维重建，并用推定的凝集素和肌动蛋白结合蛋白comitin装饰。这些重建表明，mititin主要与肌动蛋白亚结构域1高半径结合F-actin。该位置与F-actin上其他肌动蛋白捆绑蛋白（例如a-actinin家族成员）的结合位点截然不同。这是由于带正电荷的刀豆蛋白与亚结构域1中肌动蛋白N末端附近的带负电荷的位点相互作用而引起的。在单个肌动蛋白单体上，委员会的结合蛋白位点的位置及其对亚结构域1的限制与具有与其他肌动蛋白-结合蛋白，例如，使commitin能够将捆绑的肌动蛋白丝连接到高尔基体上。（C）1998年学术出版社。 [参考：38]

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《Journal of Molecular Biology》 |1998年第5期|共9页
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Fulgenzi G.; Granata AL.; Corsi A.; Fucini P.; Noegel AA. Kent HM.; Stewart M.; Graciotti L.;
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中图分类分子生物学;
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2. Location of the binding site of the mannose-specific lectin comitin on F-actin [J] . Fulgenzi G., Granata AL., Corsi A., Journal of Molecular Biology . 1998,第5期

机译：甘露糖特异性凝集素commitin在F-肌动蛋白上的结合位点的位置
3. Carbohydrate-binding sites of the mannose-specific fimbrial lectins of enterobacteria. [J] . N Firon, I Ofek, N Sharon Infection and immunity . 1984,第3期

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4. Loss of the F-Actin Binding and Vesicle-Associated Protein Comitin Leads to a Phagocytosis Defect [J] . Thomas Schreiner, Martina R. Mohrs, Rosemarie Blau-Wasser, Eukaryotic cell . 2002,第6期

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机译：连接微丝到细胞内膜：肌动蛋白结合和囊泡相关的蛋白质comitin表现出甘露糖特异性凝集素活性。
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机译：使用BIacore测定溶组织内阿米巴半乳糖粘附凝集素补体 - 裂解增强单克隆抗体3D12的独特表位结合位点

Location of the binding site of the mannose-specific lectin comitin on F-actin

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