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首页> 外文期刊>Journal of Molecular Biology >Somatic insertions and deletions shape the human antibody repertoire.
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Somatic insertions and deletions shape the human antibody repertoire.

机译：体细胞插入和缺失塑造了人类抗体库。

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摘要

We have sequenced the heavy and light chain genes from 365 IgG(+) B cells and found that 24 (6.5 %) contain somatically introduced insertions or deletions. These insertions and deletions are clustered at "hot-spots" in the antigen-binding site and frequently result in the creation of new combinations of canonical loop structures or entirely new loops that are not present in the human germline repertoire, but are similar to those seen in other species. Somatic insertion and deletion therefore provides a further mechanism for introducing structural diversity into antibodies in addition to somatic point mutation and receptor editing, which have small (single amino acid changes) and large (chain replacement) impacts on structural diversity, respectively. Copyright 1999 Academic Press.
机译：我们已经对365个IgG（+）B细胞的重链和轻链基因进行了测序，发现24个（6.5％）包含体细胞引入的插入或缺失。这些插入和缺失聚集在抗原结合位点的“热点”处，并经常导致创建规范环结构的新组合或人类种系库中不存在但与之相似的全新环在其他物种中看到。因此，体细胞插入和缺失提供了进一步的机制，以将结构多样性引入到抗体中，除了体点突变和受体编辑外，这分别对结构多样性具有较小的影响（单个氨基酸变化）和较大的影响（链置换）。版权所有1999，学术出版社。

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