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首页> 外文期刊>Journal of Molecular Biology >DNA microloops and microdomains: A general mechanism for transcription activation by torsional transmission [Review]
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DNA microloops and microdomains: A general mechanism for transcription activation by torsional transmission [Review]

机译：DNA微环和微结构域：通过扭转传递激活转录的一般机制[综述]

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Prokaryotic transcriptional activation often involves the formation of DNA microloops upstream of the polymerase binding site. There is substantial evidence that these microloops function to bring activator and polymerase into close spatial proximity. However additional functions are suggested by the ability of certain activators, of which FIS is the best characterised example, to facilitate polymerase binding, promoter opening and polymerase escape. We review here the evidence for the concept that the topology of the microloop formed by such activators is tightly coupled to the structural transitions in DNA mediated by RNA polymerase. In this process, which we term torsional transmission, a major function of the activator is to act as a local topological homeostat. We argue that the same mechanism may also be employed in site-specific DNA inversion. (C) 1998 Academic Press. [References: 118]
机译：原核转录激活通常涉及聚合酶结合位点上游DNA微环的形成。有大量证据表明，这些微环起到使激活剂和聚合酶紧密接近空间的作用。然而，某些活化剂的能力暗示了附加功能，其中FIS是最典型的实例，其促进聚合酶结合，启动子打开和聚合酶逃逸。我们在这里复查有关这种激活剂形成的微环拓扑结构紧密耦合到由RNA聚合酶介导的DNA结构转变的概念的证据。在这个我们称为扭转传递的过程中，激活剂的主要功能是充当局部拓扑稳态器。我们认为相同的机制也可以用于位点特异性DNA转化。 （C）1998年学术出版社。 [参考：118]

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