On the requirement of oxidizing reagent for the formation of a disulfide bond.

Berezhkovskiy LM; Deshpande SV

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On the requirement of oxidizing reagent for the formation of a disulfide bond.

机译：对形成二硫键的氧化剂有要求。

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Cyclization of a peptide through the formation of a disulfide bond between the SH groups of cysteines on the N- and C-terminals of peptide was studied in degassed water solution under vacuum. Cyclization went to completion although the solution was oxygen deficient (the number of oxygen molecules available for the reaction was at least 16 times less than the number of peptide molecules). This result indicates that, contrary to the common assumption, disulfide bond formation does not necessarily require an oxidant (O(2), I(2), etc.) to occur.

机译：在真空脱气的水溶液中研究了通过在肽的N和C端的半胱氨酸的SH基团之间形成二硫键来使肽环化。尽管溶液缺氧（尽管可用于反应的氧分子数至少比肽分子数少16倍），环化仍完成。该结果表明，与通常的假设相反，二硫键的形成并不一定需要氧化剂（O（2），I（2）等）的发生。

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来源
《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2001年第3期|共9页
作者
Berezhkovskiy LM; Deshpande SV;
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原文格式 PDF
正文语种 eng
中图分类生物化学;生物物理学;
关键词
Disulfides; Oxidants; Indicators and Reagents; Peptides; Cyclic; 二硫化物类; 氧化剂;

机译：Disulfides;Oxidants;Indicators and Reagents;Peptides;Cyclic;二硫化物类;氧化剂;

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1. On the requirement of oxidizing reagent for the formation of a disulfide bond. [J] . Berezhkovskiy LM, Deshpande SV Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2001,第3期

机译：对形成二硫键的氧化剂有要求。
2. Photolysis of recombinant human insulin in the solid state: formation of a dithiohemiacetal product at the C-terminal disulfide bond. [J] . Olivier Mozziconacci, Jessica Haywood, Eric M Gorman, Pharmaceutical research . 2012,第1期

机译：固态重组人胰岛素的光解：在C端二硫键处形成二硫代半缩醛产物。
3. N-terminal insertion of alamethicin in channel formation studied using its covalent dimer N-terminally linked by disulfide bond. [J] . Sakoh M, Okazaki T, Nagaoka Y, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2003,第1期

机译：使用其二价键通过二硫键连接的共价二聚体，研究了通道中芳香胺的N端插入。
4. Improved reagents and software for comparing biosimilar and originator therapeutic proteins: Accurate analysis of deamidationand disulfide bond scrambling [C] . Wilfred H. Tang, Marshall Bern, St John Skilton, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：改进的试剂和软件，用于比较生物仿制剂和发起者治疗蛋白质：准确分析脱胺和二硫键加扰
5. Thiol--Disulfide Interchange: Design, Synthesis, and Evaluation of Reagents and Organocatalysts for Chemical Biology. [D] . Lukesh, John C., III. 2014

机译：硫醇-二硫键交换：化学生物学试剂和有机催化剂的设计，合成和评估。
6. Kinetic and thermodynamic analysis of the conformational folding process of SS-reduced bovine pancreatic ribonuclease A using a selenoxide reagent with high oxidizing ability [O] . Kenta Arai, Fumio Kumakura, Michio Iwaoka -1

机译：使用具有高氧化能力的硒氧化物试剂对SS还原的牛胰核糖核酸酶A进行构象折叠过程的动力学和热力学分析
7. New reagents. IV. Oxidizing reagents. Tl(OCOCF3)3 as a disulfide bond-forming reagent. [O] . Akira OTAKA, Nobutaka FUJII 1990

机译：新试剂。 IV。氧化试剂。 T1（ococf3）3作为二硫键形成试剂。
8. Formation/stabilization of the water oxidizing complex: Polypeptide/secondary donor requirement. Progress report [R] . 1992

机译：水氧化复合物的形成/稳定化：多肽/二级供体需求。进度报告

On the requirement of oxidizing reagent for the formation of a disulfide bond.

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