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首页> 外文期刊>Journal of neurotrauma >Acute effects of calvarial damage on dural mast cells, pial vascular permeability, and cerebral cortical histamine levels in rats and mice.
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Acute effects of calvarial damage on dural mast cells, pial vascular permeability, and cerebral cortical histamine levels in rats and mice.

机译：颅盖膜损伤对大鼠和小鼠硬脑膜肥大细胞，血管内皮通透性和脑皮质组胺水平的急性影响。

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Neurological complications after mild head injury can include vasogenic edema and/or subsequent development of epilepsy, conditions associated with elevated histamine. In the present study we assessed the potential of mast cells located in the dura mater to contribute to elevated cortical histamine and breakdown of the blood-brain barrier after minor head injury, modeled by either a parietal craniectomy or producing a groove in (scoring) the parietal bone surface to model a grazing head injury. We measured the following effects at 5-20 min after a unilateral parietal craniectomy (rats) or unilateral scoring of the parietal bone (mice): (1) mast cell integrity in subjacent dura mater; (2) subjacent vs. contralateral histamine in dura mater and cerebral cortex; (3) vascular permeability of cerebral cortical blood vessels subjacent to the injury, and; (4) the effects of an H(2)-receptor antagonist on cerebral cortical vascular permeability. RESULTS: Dural mast cells subjacent to the craniectomy became activated (degranulated) concomitant with (1) decreased histamine in dura mater subjacent to the craniectomy; (2) increased histamine in the subjacent cerebral cortex; and (3) extravasation of Evans blue-albumin which stained the subjacent cerebral cortex, indicating a localized breakdown of the blood-brain barrier. Similar results were observed in mice after scoring the parietal bone surface and, additionally, pretreatment with the histamine H(2)-receptor antagonist zolantadine (1 h before injury) dose-dependently inhibited extravasation of Evans blue-albumin. We conclude that even a minor grazing injury of the skull, in the absence of penetrating brain injury or concussion, can activate dural mast cells and elevate cortical histamine, a novel mechanism with potential contributions to neurotraumatic complications arising from a relatively minor or grazing head wound.
机译：轻度颅脑损伤后的神经系统并发症可包括血管源性水肿和/或癫痫发作，以及与组胺升高相关的疾病。在本研究中，我们评估了硬脑膜中肥大细胞对轻度颅脑损伤后皮质组胺升高和血脑屏障破坏的潜在作用，其方法是通过顶壁颅骨切除术或在（评分）颅骨中形成凹槽顶骨表面模拟放牧性颅脑损伤。我们在单侧顶开颅骨切除术（大鼠）或单侧切开顶骨骨（小鼠）后5-20分钟测量了以下效果：（1）硬脑膜下的肥大细胞完整性; （2）硬脑膜和大脑皮层下的与对侧的组胺; （3）在损伤之后，大脑皮层血管的血管渗透性;以及（4）H（2）受体拮抗剂对大脑皮层血管通透性的影响。结果：颅骨切除术后硬脑膜肥大细胞被激活（去颗粒），同时伴有（1）颅骨切除术后硬脑膜组胺减少; （2）大脑下皮质的组胺增加; （3）伊文思蓝白蛋白的渗出，沾染了下面的大脑皮层，表明血脑屏障的局部破坏。在给小鼠顶骨表面评分后，在小鼠中观察到了相似的结果，此外，用组胺H（2）-受体拮抗剂佐兰他定（损伤前1小时）进行的剂量依赖性抑制了伊文思蓝白蛋白的外渗。我们得出的结论是，即使在没有穿透性脑损伤或脑震荡的情况下，即使是轻微的颅骨擦伤，也可以激活硬脑膜肥大细胞并升高皮质组胺，这种新的机制可能对相对较小或擦伤的头部伤口引起的神经外伤并发症做出了贡献。

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