• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Saturable entry of leukemia inhibitory factor from blood to the central nervous system.
【24h】

Saturable entry of leukemia inhibitory factor from blood to the central nervous system.

机译：白血病抑制因子从血液到中枢神经系统的饱和进入。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Leukemia inhibitory factor (LIF) is a neurotrophic cytokine now under clinical investigation for its effects on the CNS. We studied its passage across the blood-brain barrier (BBB) from blood to brain and spinal cord. Although a large amount of LIF was reversibly associated with the cerebral vasculature, intact LIF did reach brain parenchyma. Multiple-time regression analysis showed ready access of LIF to the CNS at a rate much faster than that of the vascular marker albumin. Excess LIF inhibited the entry of 125I-LIF after administration i.v. or by in-situ perfusion in blood-free buffer. Efflux of LIF from brain to blood was slower than reabsorption by CSF bulk flow, indicating that LIF tended to be retained in the brain. Although ciliary neurotrophic factor (CNTF) and LIF bind to the same receptor complex, CNTF did not cross-inhibit the entry of LIF into the CNS. A monoclonal antibody to LIF, however, abolished the entry of LIF. Our results show that peripherally administered LIF readily enters the brain and spinal cord by a saturable transport system across the BBB that may have biological implications.
机译：白血病抑制因子（LIF）是一种神经营养性细胞因子，目前因其对CNS的作用而正在临床研究中。我们研究了它从血液到大脑和脊髓的血脑屏障（BBB）通道。尽管大量LIF与脑血管系统可逆地相关，但完整的LIF确实可以达到脑实质。多次回归分析显示，LIF可以迅速进入CNS，其速度比血管标记白蛋白快得多。静脉内给药后过量的LIF抑制了125I-LIF的进入。或在无血缓冲液中原位灌注。 LIF从大脑到血液的流出比CSF大流量的重吸收慢，这表明LIF倾向于保留在大脑中。尽管睫状神经营养因子（CNTF）和LIF与相同的受体复合物结合，但CNTF不能交叉抑制LIF进入CNS。但是，针对LIF的单克隆抗体取消了LIF的进入。我们的研究结果表明，外围给药的LIF通过BBB内的饱和转运系统很容易进入大脑和脊髓，这可能具有生物学意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号