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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.
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Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.

机译：自闭症儿童神经元特异性抗原的抗体：可能与牛奶，肺炎衣原体和链球菌A组的脑致病蛋白发生交叉反应。

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摘要

We measured autoantibodies against nine different neuron-specific antigens and three cross-reactive peptides in the sera of autistic subjects and healthy controls by means of enzyme-linked immunosorbent assay (ELISA) testing. The antigens were myelin basic protein (MBP), myelin-associated glycoprotein (MAG), ganglioside (GM1), sulfatide (SULF), chondroitin sulfate (CONSO4), myelin oligodendrocyte glycoprotein (MOG), alpha,beta-crystallin (alpha,beta-CRYS), neurofilament proteins (NAFP), tubulin and three cross-reactive peptides, Chlamydia pneumoniae (CPP), streptococcal M protein (STM6P) and milk butyrophilin (BTN). Autistic children showed the highest levels of IgG, IgM and IgA antibodies against all neurologic antigens as well as the three cross-reactive peptides. These antibodies are specific because immune absorption demonstrated that only neuron-specific antigens or their cross-reactive epitopes could significantly reduce antibody levels. These antibodies may have been synthesized as a result of an alteration in the blood-brain barrier. This barrier promotes access of preexisting T-cells and central nervous system antigens to immunocompetent cells, which may start a vicious cycle. These results suggest a mechanism by which bacterial infections and milk antigens may modulate autoimmune responses in autism.
机译：我们通过酶联免疫吸附测定（ELISA）测试了自闭症患者和健康对照者血清中针对9种不同神经元特异性抗原和3种交叉反应肽的自身抗体。抗原包括髓鞘碱性蛋白（MBP），髓鞘相关糖蛋白（MAG），神经节苷脂（GM1），硫酸盐（SULF），硫酸软骨素（CONSO4），髓鞘少突胶质细胞糖蛋白（MOG），α，β-晶状蛋白（α，β -CRYS），神经丝蛋白（NAFP），微管蛋白和三种交叉反应肽，肺炎衣原体（CPP），链球菌M蛋白（STM6P）和乳酪蛋白（BTN）。自闭症儿童对所有神经系统抗原以及三种交叉反应肽的IgG，IgM和IgA抗体水平最高。这些抗体具有特异性，因为免疫吸收表明只有神经元特异性抗原或其交叉反应性表位才能显着降低抗体水平。这些抗体可能是由于血脑屏障改变而合成的。这种屏障促进了先前存在的T细胞和中枢神经系统抗原进入具有免疫能力的细胞，这可能会启动一个恶性循环。这些结果表明细菌感染和乳抗原可以调节自闭症自身免疫反应的机制。

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