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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta.
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Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta.

机译：针对实验性自身免疫性脑脊髓炎的保护性DNA疫苗接种与IFNbeta的诱导有关。

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摘要

DNA vaccines encoding encephalitogenic peptides protect against subsequent development of rat experimental autoimmune encephalomyelitis (EAE) through unknown mechanisms. We investigated immune cell phenotypes at different time points after DNA vaccination with vaccine encoding myelin oligodendrocyte glycoprotein peptide 91-108 and subsequent induction of EAE. In protected rats, we observed (i) no alterations in antigen-specific Th2 or Th3 responses, (ii) reduced MHC II expression on splenocytes early after EAE induction, (iii) antigen-specific upregulation of IFNbeta upon recall stimulation and (iv) reduced IL-12Rbeta2 on lymphocytes. We suggest that the underlying mechanism of DNA vaccination is associated with immunomodulation exerted by induced IFNbeta.
机译：编码致脑原性肽的DNA疫苗可通过未知机制防止大鼠实验性自身免疫性脑脊髓炎（EAE）的后续发展。我们用编码髓鞘少突胶质细胞糖蛋白肽91-108的疫苗接种DNA和随后诱导EAE后，在不同时间点调查了免疫细胞表型。在受保护的大鼠中，我们观察到（i）抗原特异性Th2或Th3反应没有改变，（ii）EAE诱导后早期脾细胞上MHC II表达降低，（iii）回忆刺激后IFNβ的抗原特异性上调和（iv）降低淋巴细胞上的IL-12Rbeta2。我们建议DNA疫苗接种的潜在机制与诱导的IFNβ发挥免疫调节作用。

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