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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Twenty-four-hour rhythms of mitogenic responses, lymphocyte subset populations and amino acid content in submaxillary lymph nodes of growing male rats subjected to calorie restriction.
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Twenty-four-hour rhythms of mitogenic responses, lymphocyte subset populations and amino acid content in submaxillary lymph nodes of growing male rats subjected to calorie restriction.

机译：生长受限的成年雄性大鼠的二十四小时有丝分裂反应，节律性淋巴细胞亚群和下颌下淋巴结氨基酸含量的节律。

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摘要

Peripubertal male Wistar rats were submitted to a calorie restriction diet enriched in proteins and low in fat and carbohydrates for 4 weeks, and starting on day 35 of life. Mitogenic responses, lymphocyte subset populations, interferon (IFN)- gamma release and amino acid content were determined in submaxillary lymph nodes at six time intervals during the 24-h span. The diet employed completely arrested growth in growing rats. After caloric restriction, mean values of Con A response, lymph node T and CD4(+) cell number and CD4(+)/CD8(+) ratio augmented, whereas those of B cell number, IFN-gamma release and glutamine and glutamate concentration decreased. Calorie restriction modified 24-h rhythmicity of lymph node mitogenic responses to Con A and LPS, and of T, T-B, CD4(+) and CD4(+)-CD8(+) lymph node cell subsets. It also changed the 24-h pattern of lymph node IFN-gamma release and glutamine, aspartate, glutamate and taurine lymph node content. Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of immune responsiveness in growing rats.
机译：青春期前的雄性Wistar大鼠接受了热量限制饮食，该饮食富含蛋白质，脂肪和碳水化合物含量低，为期4周，从生命的第35天开始。在24小时内，在六个时间间隔内测定上颌下淋巴结中的有丝分裂反应，淋巴细胞亚群，干扰素（IFN）-γ释放和氨基酸含量。该饮食在生长中的大鼠中完全停止了生长。热量限制后，Con A应答，淋巴结T和CD4（+）细胞数以及CD4（+）/ CD8（+）比值的平均值增加，而B细胞数，IFN-γ释放以及谷氨酰胺和谷氨酸浓度升高减少了。热量限制修改了对Con A和LPS以及T，T-B，CD4（+）和CD4（+）-CD8（+）淋巴结细胞亚群的淋巴结有丝分裂反应的24小时节律。它还改变了淋巴结IFN-γ释放和谷氨酰胺，天冬氨酸，谷氨酸和牛磺酸淋巴结含量的24小时模式。营养物的可用性大概会影响调节生长中大鼠免疫应答的昼夜节律变化的机制。

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