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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum.
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Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum.

机译：通过脑脊液和血清的等电聚焦检测到的副肿瘤抗体。

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摘要

Patients with paraneoplastic neurological syndromes often produce intrathecal antibodies. We have employed isoelectric focusing and peroxidase-labeled anti-IgG or (35)S-labeled Hu or Yo antigens to identify oligoclonal bands (OCB) representing either total IgG or Hu or Yo antibodies in serum and CSF of patients with paraneoplastic encephalomyelitis (PEM) or paraneoplastic cerebellar degeneration (PCD). OCBs representing paraneoplastic antibodies were found in all CSF, but in only three sera. Yo antibodies represented the majority of IgG bands in PCD-CSF, which may reflect a limited immune response, whereas in PEM/SN, there were numerous additonal IgG bands of unknown specificity, indicating a broader immune response in these patients.
机译：副肿瘤性神经系统综合症患者通常会产生鞘内抗体。我们已采用等电聚焦和过氧化物酶标记的抗IgG或（35）S标记的Hu或Yo抗原来鉴定代表副肿瘤性脑脊髓炎（PEM）患者血清和CSF中总IgG或Hu或Yo抗体的寡克隆带（OCB） ）或癌旁小脑变性（PCD）。在所有脑脊液中均发现了代表副肿瘤抗体的OCB，但仅存在于三个血清中。 Yo抗体代表PCD-CSF中的大部分IgG带，这可能反映了有限的免疫反应，而在PEM / SN中，有许多未知特异性的附加IgG带，表明这些患者的免疫反应更广泛。

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