The antibody response to oligodendrocyte specific protein in multiple sclerosis.

Aslam M; Kalluri SR; Cepok S; Kraus V; Buck D; Srivastava R; Hemmer B

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The antibody response to oligodendrocyte specific protein in multiple sclerosis.

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The antibody response to oligodendrocyte specific protein in multiple sclerosis.

机译：多发性硬化中抗体对少突胶质细胞特异性蛋白的反应。

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The role of autoantibody responses in pathogenesis or progression of multiple sclerosis (MS) remains controversial. This is partly because the methods that can distinctly identify pathogenic antibody reactivities targeting native membrane proteins from the reactivities that originate as an epiphenomenon in such disease are just emerging. Oligodendrocyte specific protein (OSP or claudin-11) is a candidate autoantigen in MS and CSF reactivity towards OSP has been reported in MS patients. We characterized the autoantibody response to OSP using sensitive cell based assays. In line with a previous report, higher antibody response to OSP 114-120 peptide and denatured protein was observed. However applying assays based on native OSP we did not observe any specific OSP response in MS patients. Our results demonstrate that anti-OSP antibodies do not recognise native glial OSP and may therefore rather represent an epiphenomenon in MS.

机译：自身抗体反应在多发性硬化症（MS）的发病机理或进展中的作用仍存在争议。这部分是因为可以从这些疾病中以表观现象起源的反应中区别识别天然膜蛋白的致病性抗体反应的方法刚刚出现。少突胶质细胞特异性蛋白（OSP或claudin-11）是MS的候选自身抗原，MS患者中已有CSF对OSP的反应性报道。我们使用基于敏感细胞的测定法表征了对OSP的自身抗体反应。与先前的报告一致，观察到对OSP 114-120肽和变性蛋白的抗体反应更高。但是，基于天然OSP的检测方法在MS患者中未观察到任何特定的OSP反应。我们的结果表明，抗OSP抗体不能识别天然神经胶质OSP，因此可能代表MS中的一种现象。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共6页
作者
Aslam M; Kalluri SR; Cepok S; Kraus V; Buck D; Srivastava R; Hemmer B;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. The antibody response to oligodendrocyte specific protein in multiple sclerosis. [J] . Aslam M, Kalluri SR, Cepok S, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：多发性硬化中抗体对少突胶质细胞特异性蛋白的反应。
2. The antibody response to oligodendrocyte specific protein in multiple sclerosis. [J] . Aslam M, Kalluri SR, Cepok S, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：多发性硬化症中对oligodendrocyte特异性蛋白质的抗体反应。
3. Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosis. [J] . Lutterotti A, Reindl M, Gassner C, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：对髓鞘少突胶质细胞糖蛋白和髓鞘碱性蛋白的抗体应答取决于家族背景，并且与多重家族和偶发性多发性硬化中的人白细胞抗原等位基因部分相关。
4. Chapter 6 Strategies for Designing Peptide Immunogens To Elicit a-Helical Conformation-Specific Antibodies Reactive with Native Proteins [C] . Zhe Yan, Wendy J. Hartsock, Zhaohui Qian, American Chemical Society. . 2012

机译：第6章设计肽免疫原的策略，以引发与天然蛋白质反应的α-螺旋构象特异性抗体
5. Antibody responses of horses to five major glycoproteins of equine herpesvirus 1 and specificity of responses to antigenic domains of glycoproteins B and C. [D] . Ostlund, Eileen Noel. 1992

机译：马对马疱疹病毒1的5种主要糖蛋白的抗体应答以及对糖蛋白B和C抗原域的应答的特异性。
6. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. [O] . E Meinl, F Weber, K Drexler, 1993

机译：多发性硬化症中髓磷脂碱性蛋白特异性T淋巴细胞库。由于募集了多个T细胞克隆嵌套表位的响应和优势的复杂性。
7. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. [O] . Meinl, E, Weber, F, Drexler, K, 1993

机译：多发性硬化症中髓磷脂碱性蛋白特异性T淋巴细胞库。由于募集了多个T细胞克隆，嵌套表位的响应和优势的复杂性。
8. In vitro Antigen-Specific Antibody Response to the Species-Specific Surface Protein Antigens of Typhus Group Rickettsiae by Human Peripheral Blood Mononuclear Cells. Generation of an Antigen-Dependent Suppressor T Cell [R] . Misiti, J., Dasch, G. A. 1985

机译：体外抗原特异性抗体对人外周血单个核细胞对斑疹伤寒组立克次体的物种特异性表面蛋白抗原的反应。产生抗原依赖性抑制T细胞

The antibody response to oligodendrocyte specific protein in multiple sclerosis.

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