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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children.
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The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children.

机译：C4B无效等位基因与自闭症以及埃及自闭症儿童自身免疫家族史的联系。

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The reason behind the initiation of autoimmunity, which may have a role in autism, is not well understood. There is an association between some autoimmune disorders and complement (C) 4B null allele. We aimed to study the association between C4B null allele and autism. In addition, we are the first to investigate the association between this allele and a family history of autoimmune diseases in autistic children. Therefore, we examined the frequency of C4B null allele, by quantitative real-time PCR, in 80 autistic patients and 80 healthy matched-children. The frequency of C4B null allele was significantly higher in autistic patients (37.5%) than healthy controls (8.75%), P<0.001. The frequency of autoimmune diseases in families of autistic children (40%) was significantly higher than healthy children (10%), P<0.001. In addition, a family history of autoimmunity had a significant risk for association with autism (odds ratio=6, 95%, CI=2.5-14.1). C4B null allele had a significant risk for association with autism (odds ratio=6.26, 95% CI=2.55-15.36) and with a family history of autoimmunity (odds ratio=21, 95% CI=6.5-67.8). Conclusions: the link of C4B null allele to autism and to a family history of autoimmunity may indicate its possible contributing role to autoimmunity in autism.
机译：引发自身免疫的原因可能是自闭症，目前尚不清楚。一些自身免疫性疾病与补体（C）4B无效等位基因之间存在关联。我们旨在研究C4B无效等位基因与自闭症之间的关联。此外，我们是第一个研究该等位基因与自闭症儿童自身免疫性疾病家族史之间关系的人。因此，我们通过定量实时PCR检测了80名自闭症患者和80名健康配对儿童中C4B无效等位基因的频率。自闭症患者中C4B无效等位基因的频率（37.5％）显着高于健康对照组（8.75％），P <0.001。自闭症儿童家庭自身免疫疾病的发生率（40％）显着高于健康儿童（10％），P <0.001。此外，自身免疫性家族史有与自闭症相关的显着风险（几率= 6、95％，CI = 2.5-14.1）。 C4B无效等位基因与自闭症（比值比= 6.26，95％CI = 2.55-15.36）和自身免疫家族史（比值比= 21，95％CI = 6.5-67.8）有显着风险。结论：C4B无效等位基因与自闭症和自身免疫性家族史的联系可能表明其可能对自闭症中自身免疫性的贡献。

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