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Aquaporin 4, Helicobacter pylori and potential implications for neuromyelitis optica

机译:水通道蛋白4,幽门螺杆菌及其对视神经脊髓炎的潜在影响

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Dear Editor, We have read with interest the paper by Vaishnav et al. (2013), who investigated the hypothesis that antibodies to aquaporin 4 (AQP4) associated with neuromyelitis optica (NMO) can be triggered by exposure to environmental plant and bacterial proteins; high similarity to a known epitope for NMO-IgG, AQP4(207-232), was observed for corn ZmTIP4-l, and NMO patient serum showed reactivity to both peptides and to plant tissue, findings warranting further investigation regarding the role of the environmental agents in NMO etiology. Discussing their results, the authors considered that molecular mimicry is a mechanism by which exogenous agents, including plant, bacterial and viral proteins, may trigger immune responses against self or non-self antigens.
机译:亲爱的编辑,我们感兴趣地阅读了Vaishnav等的论文。 (2013),他研究了假说:暴露于环境植物和细菌蛋白可触发与视神经脊髓炎(NMO)相关的水通道蛋白4(AQP4)抗体;玉米ZmTIP4-1与NMO-IgG的已知表位AQP4(207-232)具有高度相似性,NMO患者血清对肽和植物组织均显示出反应性,这些发现值得进一步研究环境的作用NMO病因学中的药物。在讨论他们的结果时,作者认为分子模拟是一种机制,通过这种机制外源性物质(包括植物,细菌和病毒蛋白)可以触发针对自身或非自身抗原的免疫反应。

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