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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
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IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

机译：IFNγ刺激的树突状细胞外泌体作为髓鞘再生的潜在疗法

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摘要

Dendritic cells (DCs) release exosomes with different characteristics based on stimulus. Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Furthermore, nasally administered IFNγ-DC-Exos increased CNS myelination in vivo. IFNγ-DC-Exos were preferentially taken up by oligodendrocytes, suggesting that they directly impact oligodendrocytes to increase myelination. Thus, our results show great potential for use of these IFNγ-DC-Exos as a therapeutic to promote remyelination in multiple sclerosis and dysmyelinating syndromes.
机译：树突状细胞（DC）根据刺激释放具有不同特征的外泌体。在这里，我们显示了用低水平IFNγ刺激的DC培养物释放的外泌体（IFNγ-DC-Exos）含有可增加基线髓鞘形成，降低氧化应激并改善急性溶血卵磷脂诱导的脱髓鞘后的髓鞘形成的microRNA物种。此外，经鼻施用的IFNγ-DC-Exos增加了体内CNS的髓鞘形成。 IFNγ-DC-Exos优先被少突胶质细胞摄取，表明它们直接影响少突胶质细胞以增加髓鞘形成。因此，我们的结果显示出将这些IFNγ-DC-Exos用作治疗多发性硬化症和髓鞘异常综合征的髓鞘再生的巨大潜力。

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