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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis
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Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis

机译：早期多发性硬化症中血清爱泼斯坦-巴尔核抗原1抗体与鞘内免疫球蛋白合成的关系

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摘要

Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing-remitting MS, serum antibodies to Epstein-Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher (p = 0.03) in those with than those without a calculated intrathecal IgG synthesis >0% and correlated with the percentage (r = 0.27, p = 0.009) and concentration (r = 0.27, p = 0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS. (C) 2015 Elsevier B.V. All rights reserved.
机译：多发性硬化症（MS）与爱泼斯坦巴尔病毒（EBV）感染有关。 MS的特征是鞘内合成免疫球蛋白（Ig）G。在90例临床孤立综合征/早复发型MS患者中，Epstein-Barr核抗原-1而不是EBV病毒衣壳抗原，风疹或水痘带状疱疹病毒的血清抗体在这些患者中较高（p = 0.03）与未计算鞘内IgG合成> 0％且与鞘内产生的IgG的百分比（r = 0.27，p = 0.009）和浓度（r = 0.27，p = 0.012）相关。这些发现表明，EB病毒感染与MS患者导致鞘内IgG合成的事件之间存在联系。 （C）2015 Elsevier B.V.保留所有权利。

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