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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Increased serum peroxiredoxin 5 levels in myasthenia gravis
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Increased serum peroxiredoxin 5 levels in myasthenia gravis

机译：重症肌无力患者血清peroxiredoxin 5水平升高

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摘要

Extracellular peroxiredoxin 5 (PRX5) is known to be an inflammatory mediator. The serum PRX5 levels of 40 patients with anti-acetylcholine receptor antibody-positive MG and those of 40 controls were measured. PRX5 levels in patients with MG were higher than those in the controls (P = 0.045). Thymoma-associated MG patients showed higher PRX5 levels than late-onset MG patients and controls (P < 0.05). There were significant associations between the serum PRX5 levels and high mobility group box 1 levels. PRX5 elevation in MG could be related to the neuromuscular junction breakdown and plays a pivotal role in the pathogenic inflammation of MG. (C) 2015 Elsevier B.V. All rights reserved.
机译：已知细胞外过氧化物酶5（PRX5）是炎症介质。测量了40名抗乙酰胆碱受体抗体阳性的MG患者和40名对照的血清PRX5水平。 MG患者的PRX5水平高于对照组（P = 0.045）。与胸腺瘤相关的MG患者的PRX5水平高于迟发性MG患者和对照组（P <0.05）。血清PRX5水平与高迁移率分组框1水平之间存在显着关联。 MG中PRX5的升高可能与神经肌肉接头的破坏有关，在MG的致病性炎症中起关键作用。 （C）2015 Elsevier B.V.保留所有权利。

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