首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >TRPM4 mRNA expression levels in peripheral blood mononuclear cells from multiple sclerosis patients
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TRPM4 mRNA expression levels in peripheral blood mononuclear cells from multiple sclerosis patients

机译:多发性硬化症患者外周血单个核细胞中TRPM4 mRNA表达水平

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Recent studies have suggested a role of the cation channel TRPM4 in mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis (MS). We aimed to extrapolate central nervous system findings to the blood compartment by determining TRPM4 expression in peripheral blood mononuclear cells from 12 healthy controls (HC) and 64 untreated MS patients. TRPM4 mRNA expression levels were comparable between HC and MS patients with primary progressive MS (. n=. 17), secondary progressive MS (. n=. 19), and relapsing-remitting MS during clinical remission (. n=. 21) and relapses (. n=. 7). These findings do not support a role of TRPM4 in the peripheral blood compartment of MS patients.
机译:最近的研究表明阳离子通道TRPM4在介导实验性自身免疫性脑脊髓炎和多发性硬化症(MS)的神经变性中的作用。我们旨在通过确定来自12位健康对照(HC)和64位未经治疗的MS患者的外周血单个核细胞中的TRPM4表达,将中枢神经系统的发现外推至血液室。 HC和MS患者中,原发性进行性MS(。n =。19),继发性进行性MS(。n =。19)和临床缓解期间复发缓解型MS(。n =。21)和复发(。n =。7)。这些发现不支持TRPM4在MS患者的外周血室中的作用。

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