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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Factorial design analysis and optimisation of alginate-Ca-chitosan microspheres
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Factorial design analysis and optimisation of alginate-Ca-chitosan microspheres

机译：海藻酸钙壳聚糖微球的析因设计分析与优化

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摘要

The purpose of this study was to apply factorial design in order to determine the influence of the formulation factors and their interactions on several responses such as particle size, dissolution behaviour at pH 1.2 and pH 7.4 as well as production yield, during the development of budesonide loaded, chitosan coated Ca-alginate microparticles (MPs) intended for treatment of inflammatory diseases in the gastrointestinal tract. Produced drug-loaded MPs were spherical in shape, had smooth surfaces with low porosity and size range between 5 and 11 μm. Production yield for the formulations from the design varied from 19% to 50%. Optimisation was performed using central composite design setting the targets: particle size at 5.5 μm, maximised yield, suppressed dissolution at pH 1.2 and sustained release at pH 7.4. The optimised batches were identified with a combined desirability value of 0.967.
机译：这项研究的目的是应用析因设计，以便确定布地奈德开发过程中配方因子及其相互作用对几种响应的影响，例如粒径，pH 1.2和pH 7.4时的溶解行为以及生产产率载有壳聚糖涂层的Ca-藻酸盐微粒（MPs），用于治疗胃肠道炎性疾病。产生的载有药物的MP呈球形，表面光滑，孔隙率低，尺寸范围在5至11μm之间。从设计到配方的成品率从19％到50％不等。使用中心复合材料设计进行优化，设定目标：5.5 µm的粒径，最大的收率，在pH 1.2时抑制溶解以及在pH 7.4时持续释放。确定了最佳批次，合计期望值为0.967。

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