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首页> 外文期刊>Journal of nephrology. >Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent.
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Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent.

机译：腹膜透析流出物中的血管内皮生长因子（VEGF）水平。

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BACKGROUND: Long-term peritoneal dialysis (PD) patients who develop peritoneal ultrafiltration failure have an abnormally large number of capillaries and sclerotic changes in peritoneal biopsy. Peritoneal vascular endothelial growth factor (VEGF) production has been suggested to explain the higher levels in peritoneal effluent than in plasma. The high effluent VEGF levels have been related to peritoneal changes consisting of increased permeability to small molecules. To further analyze the relationship between peritoneal neoangiogenesis induced by VEGF and peritoneal transport, we studied peritoneal effluent VEGF levels in active PD patients. METHODS: VEGF levels were determined in serum and plasma, and in peritoneal effluent (PE) after 4, 8 and 15 h dwell times. RESULTS: PE VEGF levels were 58.6+/-33.7 pg/mL, with a mean VEGF D/P ratio of 0.45+/-0.29 (range 0.06-0.93). In low-transport patients (n = 7) this ratio did not differ from high-average ones (n=5) (0.48+/-0.3 and 0.41+/-0.1, NS). In multivariate analysis, the VEGF D/P ratio showed no correlation with the independent variables included in this study. VEGF levels were higher in 15 h than in 8 h effluent; so the VEGF D/P ratios were higher as well. Regression analysis showed a direct correlation between PEVEGF levels and dwell time (r: 0.57, p = 0.03), but not between VEGF D/P ratio and dwell time. PEVEGF levels directly correlated with effluent protein content. Regression analysis showed no correlation between PEVEGF levels and age, time on PD, days of peritonitis, urea and creatinine-mass transfer coefficients, ultrafiltration capacity, and accumulated glucose dose. Multivariate regression analysis showed correlation only between PEVEGF levels and dwell time, but not with the other independent variables. CONCLUSIONS: This study confirms that VEGF is present in fresh PE from PD patients at levels that suggest local production and filtration from plasma. Peritoneal effluent VEGF levels are not significantly associated with peritoneal functional parameters and background, and seem to be influenced by ultrafiltration in a dilution process. We believe that the role of VEGF in peritoneal pathophysiology is part of a complex relationship involving multiple peritoneal structures and other growth factors, including local counteracting factors for VEGF that regulate neoangiogenesis.
机译：背景：发生腹膜超滤失败的长期腹膜透析（PD）患者在腹膜活检中毛细血管数量异常增加，硬化改变。腹膜血管内皮生长因子（VEGF）的产生被认为可以解释腹膜排出物中的血浆水平高于血浆中的水平。高流出物VEGF水平与腹膜变化有关，包括对小分子的渗透性增加。为了进一步分析VEGF诱导的腹膜新生血管生成与腹膜转运之间的关系，我们研究了活动性PD患者腹膜排出的VEGF水平。方法：在4、8和15小时的保压时间后，测定血清和血浆以及腹膜流出物中的VEGF水平。结果：PE VEGF水平为58.6 +/- 33.7 pg / mL，平均VEGF D / P比为0.45 +/- 0.29（范围0.06-0.93）。在低转运患者（n = 7）中，该比例与高平均患者（n = 5）无差异（0.48 +/- 0.3和0.41 +/- 0.1，NS）。在多变量分析中，VEGF D / P比值与本研究中包括的独立变量无相关性。 15 h的VEGF水平高于8 h的流出液。因此，VEGF D / P比也更高。回归分析显示，PEVEGF水平与停留时间之间存在直接相关性（r：0.57，p = 0.03），而VEGF D / P比与停留时间之间不存在直接相关性。 PEVEGF水平直接与污水中的蛋白质含量相关。回归分析显示，PEVEGF水平与年龄，PD时间，腹膜炎天数，尿素和肌酐质量转移系数，超滤能力和累积葡萄糖剂量之间无相关性。多元回归分析显示，仅PEVEGF水平与停留时间之间存在相关性，而与其他自变量无相关性。结论：这项研究证实，PD患者新鲜PE中存在VEGF，其水平暗示了血浆中局部产生和过滤。腹膜排出的VEGF水平与腹膜功能参数和本底没有显着相关，并且似乎在稀释过程中受到超滤的影响。我们认为，VEGF在腹膜病理生理中的作用是涉及多个腹膜结构和其他生长因子（包括调节新生血管生成的VEGF的局部抵消因子）的复杂关系的一部分。

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