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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Polyethylenglycol-co-poly-D,L-lactide copolymer based microspheres: Preparation, characterization and delivery of a model protein
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Polyethylenglycol-co-poly-D,L-lactide copolymer based microspheres: Preparation, characterization and delivery of a model protein

机译：基于聚乙二醇-共-D-L-丙交酯共聚物的微球：模型蛋白的制备，表征和传递

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Purpose: To prepare and characterize polyethylenglycol-co-poly-D,L-lactide (PEG-d,l-PLA) multiblock copolymer microspheres containing ovalbumin. Microsphere batches made of Poly-D,L-lactide (PLA) homopolymers were prepared in order to evaluate how the presence of PEG segments into PEG-d,l-PLA copolymer could affect the behaviour of microspheres as carrier of protein drugs. Methods: The PEG-d,l-PLA and PLA microspheres, loaded with the model protein ovalbumin, were prepared using double emulsion solvent evaporation method. The effect of PEG segments in the microparticles matrix, on the morphology, size distribution, encapsulation efficiency and release behaviour was studied. Results: According to the results, PEG-d,l-PLA microspheres were more hydrophilic than PLA microparticles and with lower glass transition temperature. The surface of PEG-d,l-PLA microspheres was not as smooth as that of PLA microparticles, the mean diameter of PEG-d,l-PLA microparticles was bigger than that of PLA microspheres. Protein release from the microspheres was affected by the morphological structure of PEG-d,l-PLA microspheres and properties of PEG-d,l-PLA copolymer. This study suggests that PEG-d,l-PLA multiblock copolymer may be used as carrier in protein delivery systems for different purposes.
机译：目的：制备并表征含有卵白蛋白的聚乙二醇共聚D，L-丙交酯（PEG-d，1-PLA）多嵌段共聚物微球。制备由聚-D，L-丙交酯（PLA）均聚物制成的微球批次，以评估PEG-d，1-PLA共聚物中PEG片段的存在如何影响微球作为蛋白质药物载体的行为。方法：采用双乳剂溶剂蒸发法制备载有模型蛋白卵清蛋白的PEG-d，1-PLA和PLA微球。研究了PEG片段在微粒基质中对形态，尺寸分布，包封效率和释放行为的影响。结果：根据结果，PEG-d，1-PLA微球比PLA微粒更亲水并且具有较低的玻璃化转变温度。 PEG-d，1-PLA微球的表面不如PLA微粒光滑，PEG-d，1-PLA微粒的平均直径大于PLA微粒。从微球中释放的蛋白质受到PEG-d，1-PLA微球的形态结构和PEG-d，1-PLA共聚物性能的影响。该研究表明，PEG-d，1-PLA多嵌段共聚物可以在蛋白质递送系统中用作载体用于不同目的。

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