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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and characterization of d, l-PLA loaded 17-β-Estradiol valerate by emulsion/evaporation methods
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Preparation and characterization of d, l-PLA loaded 17-β-Estradiol valerate by emulsion/evaporation methods

机译：乳液/蒸发法制备负载d，l-PLA的17-β-雌二醇戊酸酯

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PLA microparticles containing 17-β-estradiol valerate were prepared by an emulsion/evaporation method in order to sustain drug release. This system was characterized concerning particle size, particle morphology and the influence of formulation and processing parameters on drug encapsulation and in vitro drug release. The biodegradation of the microparticles was observed by tissue histological analysis. Scanning electron microscopy and particle size analysis showed that the microparticles were spherical, presenting non-aggregated homogeneous surface and had diameters in the range of 718-880 nm (inert microparticles) and 3-4 μm (drug loaded microparticles). The encapsulation efficiency was ~80%. Hormone released from microparticles was sustained. An in vivo degradation experiment confirmed that microparticles are biodegradable. The preparation method was shown to be suitable, since the morphological characteristics and efficiency yield were satisfactory. Thus, the method of developed microparticles seems to be a promising system for sustained release of 17-β-estradiol.
机译：为了维持药物释放，通过乳液/蒸发法制备了含有17-β-雌二醇戊酸酯的PLA微粒。该系统的特征涉及粒径，颗粒形态以及制剂和加工参数对药物包封和体外药物释放的影响。通过组织组织学分析观察到微粒的生物降解。扫描电子显微镜和粒度分析表明，该微粒是球形的，呈现出非聚集的均匀表面，并且直径在718-880nm（惰性微粒）和3-4μm（载药微粒）的范围内。封装效率为〜80％。从微粒释放的激素得以持续。体内降解实验证实了微粒是可生物降解的。由于形态特征和有效产率令人满意，因此表明该制备方法是合适的。因此，开发的微粒方法似乎是持续释放17-β-雌二醇的有前途的系统。

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