...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Amphotericin B microspheres: A therapeutic approach to minimize toxicity while maintaining antifungal efficacy
【24h】

Amphotericin B microspheres: A therapeutic approach to minimize toxicity while maintaining antifungal efficacy

机译：两性霉素B微球：一种在保持抗真菌功效的同时将毒性降至最低的治疗方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Amphotericin B microsphere formulations with and without addition of polyethylene glycol 2000 in cross-linked bovine serum albumin were prepared. Amphotericin B microspheres were characterized for particle size (<5 μm), zeta potential (~30 mV) and drug interaction by DSC and FTIR and were found to be stable formulations. Drug release profiles for these microspheres revealed that the release was primarily by diffusion. In vitro toxicity as assessed by release of haemoglobin and potassium demonstrated no toxic effect as compared with conventional solution formulation. Antifungal activity in vitro was comparable to solution formulation when tested by broth dilution method.
机译：制备在交联的牛血清白蛋白中添加和不添加聚乙二醇2000的两性霉素B微球制剂。通过DSC和FTIR对两性霉素B微球的粒径（<5μm），ζ电位（〜30 mV）和药物相互作用进行了表征，发现它们是稳定的制剂。这些微球的药物释放曲线表明，释放主要是通过扩散。通过血红蛋白和钾的释放评估的体外毒性与常规溶液制剂相比没有毒性作用。当通过肉汤稀释法测试时，体外抗真菌活性与溶液制剂相当。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号