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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems
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Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems

机译：壳聚糖涂层在脂质体表面上对纳米载体体系理化性质和释放曲线的影响

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摘要

Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.1-0.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.1-0.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
机译：通过超声均质化制备的壳聚糖包衣的包含etofenprox或α-氯氰菊酯的纳米脂质体保持了纳米范围内的尺寸分布。使用不同类型和浓度的壳聚糖构建纳米脂质体，以调节平均大小和表面电荷。随着壳聚糖浓度（0.1-0.5％，w / v）和脱乙酰度的增加，表面电荷也增加。包封效率和释放曲线通过气相色谱法测量。随着壳聚糖浓度的增加，包封效率略有下降（0.1-0.5％，w / v）。随着包衣材料的固有表面电荷或浓度增加，被包埋的芯材料的释放时间延长（壳聚糖A和B; 0.1和0.3％，w / v）。结果表明，不同的制备条件可能会影响所得纳米载体系统的理化性质和释放曲线。

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