PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex

I. M. Le-Deygen; E. V. Kudryashova

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PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex

机译：PEG-壳聚糖作为脂质体悬浮液的透视稳定剂：分子量和聚乙二醇化程度对复合物的物理化学性质的影响

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摘要

The possibility of regulating the physicochemical properties (stability, size, and binding sites) of liposomal containers for drug delivery by selecting the molecular weight and degree of modification of PEG-chitosan is demonstrated. The effect of the regulation of the release of doxorubicin from liposomal containers depending on the properties of the polymer and pH is demonstrated.

机译：证明了通过选择分子量和改性PEG-壳聚糖的分子量和改性来调节脂质体容器的物理化学性质（稳定性，尺寸和结合位点）的可能性。证明了根据聚合物和pH的性质对脂质体容器释放的释放多柔比蛋白的影响。

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来源
《Moscow University Chemistry Bulletin》 |2018年第2期|共5页
作者
I. M. Le-Deygen; E. V. Kudryashova;
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作者单位

Department of Chemistry Moscow State University;

Department of Chemistry Moscow State University;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
doxorubicin; liposomes; chitosan; Fourier-transform infrared spectroscopy;

机译：多柔比星;脂质体;壳聚糖;傅立叶变换红外光谱;

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1. PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex [J] . I. M. Le-Deygen, E. V. Kudryashova Moscow University Chemistry Bulletin . 2018,第2期

机译：PEG-壳聚糖作为脂质体悬浮液的透视稳定剂：分子量和聚乙二醇化程度对复合物的物理化学性质的影响
2. Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation [J] . Jolanta Kumirska, Jorg Th#x000F6, ming, Polymers . 2011,第4期

机译：几丁质/壳聚糖基材料的生物医学活性-除分子量和N-乙酰化程度外，对理化性质的影响
3. Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity. [J] . Fossheim SL, Klaveness J, Muller RN, Magnetic resonance imaging: An International journal of basic research and clinical applications . 1999,第1期

机译：顺磁性脂质体作为MRI造影剂：脂质体理化性质对体外松弛度的影响。
4. THE INFLUENCE OF POLYMERIZATION DEGREE ON THE PROPERTIES OF ULTRAHIGH MOLECULAR WEIGHT POLYETHLENE [C] . Anisimova O. A., Annenkov Yu. M., Kim V. S. International Conference Modern Technique And Technologies . 2008

机译：聚合程度对超高分子量聚乙烯性能的影响
5. Surimi wash water treatment by chitosan-alginate complexes: Effect of molecular weight and degree of deacetylation of chitosan and nutritional evaluation of solids recovered by the treatment. [D] . Wibowo, Singgih. 2004

机译：壳聚糖-藻酸盐复合物对鱼糜洗涤水的处理：壳聚糖的分子量和脱乙酰度的影响以及通过处理回收的固体的营养评估。
6. Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles [O] . Christine Rangger, Anna Helbok, Elisabeth von Guggenberg, 2012

机译：聚乙二醇化和RGD负载量对放射性标记脂质体纳米颗粒靶向性的影响
7. Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation [O] . Mirko X. Weinhold, Piotr Stepnowski, Jorg Thöming, 2011

机译：甲壳素/壳聚糖基材料的生物医学活性 - 物理化学性质的影响除了分子量和N-乙酰化程度

PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex

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