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Biofunctional textiles prepared with liposomes: in vivo and in vitro assessment

机译:用脂质体制备的生物功能纺织品:体内和体外评估

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摘要

A sun filter. Ethyl hexyl methoxycinnamate (EHMC) used as a tracer, was vehiculized by liposomes made up of internal wool lipids (IWL) or phosphatidylcholine (PC) and applied onto cotton and polyamide fabrics by exhaustion treatments. After topical applications of textiles on human volunteers, skin properties were evaluated by non-invasive biophysical techniques. Two methodologies based on percutaneous absorption were used to determine the content of the active principle penetration into the skin. PC liposomes showed more affinity for the fabric than IWL liposomes. Moreover, polyamide fabrics absorbed a slightly higher percentage of liposomes than cotton fabrics. A significantly higher amount of EHMC skin penetration was found when the biofunctional textiles were topically applied than when formulations were applied onto the skin. Moreover, the polyamide was the fibre with the highest released properties in all cases.
机译:防晒霜。用作示踪剂的甲氧基肉桂酸乙基己酯(EHMC)通过由内部羊毛脂(IWL)或磷脂酰胆碱(PC)组成的脂质体进行载体化,并通过精疲力尽的处理方法应用于棉和聚酰胺织物上。在人类志愿者上局部使用纺织品后,通过无创生物物理技术评估了皮肤特性。基于透皮吸收的两种方法被用来确定有效成分渗透到皮肤中的含量。 PC脂质体比IWL脂质体对织物的亲和力更高。而且,聚酰胺织物比棉织物吸收的脂质体百分比略高。当将生物功能纺织品局部施用时,发现比在皮肤上施用制剂时,EHMC皮肤渗透量明显更高。此外,聚酰胺是在所有情况下具有最高释放性能的纤维。

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