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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice
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Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice

机译：携带抗坏血酸棕榈酸酯的阿霉素聚乙二醇化脂质体在荷瘤实体小鼠中的生物分布

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The aim of this study is to develop ascorbyl palmitate (ASP) loaded doxorubicin (DOX) pegylated liposomes and to evaluate their targeting potential to tumor. We have prepared conventional (DL), pegylated DOX liposomes with (SDL) and without ascorbyl palmitate (SDL-A). The vesicle size in all the formulations was within the range 105-120 nm and in vitro release studies in serum confirmed the stability of the liposomes. Biodistribution studies carried out in Ehrlich ascites tumor bearing mice indicate higher area under the curve for SDL and SDL-A liposomes compared to DL and plain drug solution. Drug targeting index assessed from tumor-to-serum concentration ratio and therapeutic availability of DOX in tumor tissue was also significantly higher for pegylated liposomes. In conclusion, biodistribution study reveals that the presence of ascorbyl palmitate alters the distribution pattern of liposomes and paves way for better drug targeting.
机译：这项研究的目的是开发棕榈酸抗坏血酸棕榈酸酯（ASP）负载的阿霉素（DOX）聚乙二醇化脂质体，并评估其对肿瘤的靶向潜力。我们已经制备了具有（SDL）和不含抗坏血酸棕榈酸酯（SDL-A）的常规（DL），聚乙二醇化DOX脂质体。所有制剂中的囊泡大小在105-120nm的范围内，并且在血清中的体外释放研究证实了脂质体的稳定性。在Ehrlich腹水荷瘤小鼠中进行的生物分布研究表明，与DL和普通药物溶液相比，SDL和SDL-A脂质体的曲线下面积更大。对于聚乙二醇化脂质体，从肿瘤与血清的浓度比和DOX在肿瘤组织中的治疗有效性评估的药物靶向指数也明显更高。总之，生物分布研究表明，抗坏血酸棕榈酸酯的存在改变了脂质体的分布方式，为更好地靶向药物铺平了道路。

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