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Nanoparticles and the skin - applications and limitations

机译:纳米粒子和皮肤-应用和局限性

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摘要

In recent years, nanotechnology and nanoengineering have stimulated much research in the field of drug delivery. This review examines the different types of non-deformable nanoparticles (NP) which have been developed for pharmaceutical applications. Metal, metallic oxide, polymeric, starch, quantum dot, fullerene and carbon nanotube NP are discussed. Only those studies which have focused on particle interaction with human and porcine skin models in vitro and in vivo are considered. Particular emphasis is given to the disposition and transfer of NP in the skin. As the methodology and experimental design of published studies should have an impact on the results obtained, these are also critically examined.
机译:近年来,纳米技术和纳米工程技术激发了药物输送领域的大量研究。这篇评论检查了已开发用于药物应用的不同类型的不可变形纳米粒子(NP)。讨论了金属,金属氧化物,聚合物,淀粉,量子点,富勒烯和碳纳米管NP。仅考虑那些专注于粒子在体外和体内与人和猪皮肤模型相互作用的研究。特别强调NP在皮肤中的分布和转移。由于已发表研究的方法和实验设计应该对所获得的结果产生影响,因此,也必须对其进行严格审查。

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