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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Controlling lipid nanoemulsion digestion using nanolaminated biopolymer coatings
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Controlling lipid nanoemulsion digestion using nanolaminated biopolymer coatings

机译：使用纳米层压生物聚合物涂层控制脂质纳米乳剂的消化

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摘要

The influence of nanolaminated biopolymer coatings around lipid droplets on their physical stability and in vitro digestibility by pancreatic lipase was studied. An electrostatic deposition method was used to form primary, secondary and tertiary emulsions containing lipid droplets coated by: 1°,β-lactoglobulin (β-Lg); 2°, β-Lg-alginate; 3°, β-Lg-alginate-chitosan. The influence of pH (3-7), calcium concentration (5 or 20 mM) and oil type (long vs. medium chain triglycerides) on their physical stability and lipid digestibility was examined. Biopolymer layers had little impact on lipid digestion at 5mM calcium suggesting that they became detached from the droplet surfaces, but they slowed down digestion considerably at 20 mM calcium, suggesting the formation of a calcium alginate gel that restricted lipases access to emulsified lipids. This study has important implications for design of delivery systems to control lipid digestion and release.
机译：研究了脂滴周围的纳米化生物聚合物涂层对其物理稳定性和胰脂肪酶体外消化率的影响。使用静电沉积法形成包含脂质液滴的伯，仲和叔乳剂，所述脂质液滴被1°，β-乳球蛋白（β-Lg）包被; 2°，β-Lg-藻酸盐; 3°，β-Lg-藻酸盐-壳聚糖。检查了pH（3-7），钙浓度（5或20 mM）和油类型（长链甘油三酸酯与中链甘油三酸酯）对其物理稳定性和脂质消化率的影响。生物聚合物层对5mM钙的脂质消化几乎没有影响，表明它们从液滴表面脱落，但在20mM钙时它们显着减慢了消化速度，这表明藻酸钙凝胶的形成限制了脂肪酶进入乳化脂质。这项研究对控制脂质消化和释放的输送系统的设计具有重要意义。

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