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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Encapsulation of cationic peptides into polymersomes through in situ gelatinization
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Encapsulation of cationic peptides into polymersomes through in situ gelatinization

机译：通过原位糊化将阳离子肽包封到多聚体中

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摘要

Encapsulation of peptides and proteins remains an obstacle in drug nanoformulations. Here, we established an alternative method to encapsulate peptides and proteins into polymersomes (POs). NC-1900, a type of cationic peptide that can induce the gelatinization of deacetylated gellan gum (DGG), was selected as a model peptide. DGG was first trapped in POs to serve as a reservoir to capture NC-1900. Analysis of the optimized formulation revealed that the drug-loading capability of NC-1900-loaded POs was 1.20%, and the encapsulation efficiency was 30%. The release of NC-1900 from the gel was the rate-limiting step and could be expressed by Fick's law of diffusion. These results indicated that the preparation of POs encapsulated with gelatin couid be employed as an effective loading method for ionic peptides and proteins.
机译：肽和蛋白质的封装仍然是药物纳米制剂的障碍。在这里，我们建立了一种将肽和蛋白质封装到多聚体（POs）中的替代方法。选择一种可以诱导脱乙酰基结冷胶（DGG）糊化的阳离子肽NC-1900作为模型肽。 DGG首先被困在PO中，用作捕获NC-1900的储层。对优化配方的分析表明，NC-1900负载的POs的载药量为1.20％，包封效率为30％。 NC-1900从凝胶中的释放是限速步骤，可以用菲克扩散定律表示。这些结果表明，用明胶包裹的PO的制备可用作离子肽和蛋白质的有效上样方法。

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