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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >The pharmacokinetics of recombinant human interferon-alpha-2b poly(lactic-co-glycolic acid) microspheres in rats
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The pharmacokinetics of recombinant human interferon-alpha-2b poly(lactic-co-glycolic acid) microspheres in rats

机译：重组人干扰素-α-2b聚乳酸-乙醇酸微球在大鼠体内的药代动力学

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摘要

lnterferon-alpha2b (IFN α-2b) microspheres were prepared at various concentrations (5%, 10%, 15%, 20% and 25%) and viscosities (0.39, 0.6, 0.89 and 1.13 dL/g) of poly(lactic-co-glycolic acid) (PLGA) using double emulsion solvent evaporation. The optimal formulation of IFN α-2b microspheres was determined to be 0.89 dL/g PLGA, as assessed by the in vitro release test. The pharmacokinetics of IFN α-2b microspheres was investigated. Nine groups of rats were injected intramuscularly with three doses (0.5, 1 and 2 MIU) of commercial lyophilized IFNα-2b injection or IFN α-2b microspheres. At a dose of 0.5 MIU, the IFN α-2b microsphere released significantly longer than that of the IFN α-2b injection. At a dose of 2 MIU, each pharmacokinetics parameter of microspheres prepared with the IFNa-2b stock solution was manifestly greater than those of the injection. Our study indicated that the IFN α-2b microspheres prepared in 15% of 0.89 dL/g PLGA provided a sustained drug effect for up to 21 days in rats.
机译：制备了各种浓度（5％，10％，15％，20％和25％）和粘度（0.39、0.6、0.89和1.13 dL / g）的IFN-α2b（IFNα-2b）微球。 （双乙醇酸）（PLGA）使用双乳液溶剂蒸发。通过体外释放试验评估，确定IFNα-2b微球的最佳配方为0.89 dL / g PLGA。研究了IFNα-2b微球的药代动力学。九组大鼠肌肉注射三剂（0.5、1和2 MIU）商业冻干的IFNα-2b注射液或IFNα-2b微球。在0.5 MIU的剂量下，IFNα-2b微球的释放时间明显长于IFNα-2b注射剂的释放时间。剂量为2 MIU时，用IFNa-2b储备液制备的微球的每个药代动力学参数明显大于注射剂。我们的研究表明，以0.89 dL / g PLGA中的15％制备的IFNα-2b微球在大鼠中可提供长达21天的持续药物作用。

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