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Encapsulation of folic acid and its stability in sodium alginate-pectin-poly(ethylene oxide) electrospun fibres

机译:叶酸在藻酸钠-果胶-聚环氧乙烷电纺纤维中的包封及其稳定性

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摘要

In this study, we investigated the effect of alginate-pectin-poly(ethyIene oxide) (PEO) electrospun fibres on the stability of folic acid. Fibre-forming solutions containing folic acid were prepared by blending low- or medium-viscosity alginate with pectin. PEO was added to make the electrospinning process possible. Folic acid encapsulated in electrospun fibres achieved close to 100% retention when stored in the dark at pH 3 after 41 days of storage. By contrast, recovery of unencapsulated folic acid was 0% and 8% within the first day when stored at pH 3 in the presence and the absence of light, respectively. Electrospun fibres produced from the combination of alginate-pectin resulted in higher retention of folic acid compared to that of alginate alone. Nucleic magnetic resonance and FTIR results show that folic acid has been encapsulated in electrospun fibres through physical entrapment.
机译:在这项研究中,我们研究了藻酸盐-果胶-聚环氧乙烷(PEO)电纺丝纤维对叶酸稳定性的影响。通过将低或中等粘度的海藻酸盐与果胶混合来制备含有叶酸的成纤维溶液。添加PEO使静电纺丝过程成为可能。储存41天后,封装在静电纺丝纤维中的叶酸在黑暗中于pH 3下保存时,保留率接近100%。相比之下,当在有光和无光条件下在pH 3下储存时,第一天未封装的叶酸的回收率分别为0%和8%。与单独藻酸盐相比,由藻酸盐-果胶组合产生的电纺丝纤维具有更高的叶酸保留率。核磁共振和FTIR结果表明,叶酸已通过物理包裹被包裹在电纺纤维中。

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