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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Tyrosinase inhibitor-loaded microsponge drug delivery system: new approach for hyperpigmentation disorders
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Tyrosinase inhibitor-loaded microsponge drug delivery system: new approach for hyperpigmentation disorders

机译：装载酪氨酸酶抑制剂的微海绵药物递送系统：色素沉着过度的新方法

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Objective: The aim of the present investigation was to design and formulate appropriate form of glabridin, using microsponge drug delivery system. Method: Microsponges were prepared by emulsion solvent evaporation method and characterized by drug loading, infrared spectroscopy and scanning electron microscopy. In vitro diffusion studies of gel formulation were performed using ethanol: phosphate buffer (1:1) mixture as receptor medium. Animal studies were carried out using brownish guinea pigs with UV-induced pigmentation model. Results: Prepared microsponges were predominantly yellowish, free-flowing and spherical in shape. The infrared spectra revealed the absence of drug polymer interaction. Scanning electron microscopy (SEM) and porosity studies confirmed spherical and porous nature. In vitro release studies data depicted highest correlation with Higuchi treatment. Animal studies also supported the better depigmenting activity as compared to plain gel. Conclusion: Glabridin microsponge-loaded gel could be efficacious in treating various hyperpigmentation disorders.
机译：目的：本研究的目的是使用微海绵药物递送系统设计和配制适当形式的麦角蛋白。方法：采用乳液溶剂蒸发法制备微海绵，并通过载药，红外光谱和扫描电子显微镜对其进行表征。使用乙醇：磷酸盐缓冲液（1：1）混合物作为受体介质进行凝胶制剂的体外扩散研究。使用具有紫外线诱导的色素沉着模型的棕褐色豚鼠进行动物研究。结果：制备的微海绵主要为淡黄色，自由流动和球形。红外光谱显示不存在药物聚合物相互作用。扫描电子显微镜（SEM）和孔隙率研究证实了球形和多孔性。体外释放研究数据表明与Higuchi处理的相关性最高。动物研究也支持与普通凝胶相比更好的脱色活性。结论：加用格列本汀微海绵的凝胶可有效治疗各种色素沉着过度症。

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